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Wiley InterScience | ||||||||||
  Headache: The Journal of Head and Face PainVolume 23 Issue 5, Pages 206 - 210 Published Online: 22 Jun 2005 © 2010 American Headache Society Published on behalf of the American Headache Society
Abstract | Full Text: PDF (Size: 40K) | Related Articles | Citation Tracking  Ibuprofen Versus Aspirin and Placebo in the Treatment of Muscle Contraction Headache *Adjunct Associate Professor of Pharmacology, The Chicago Medical School. This study was supported by a grant from The Upjohn Company. Ibuprofen, aspirin, and matching placebo were supplied by The Upjohn Company. Copyright © 1983 American Headache Society (formerly the American Association for the Study of Headache) ABSTRACTSYNOPSIS One hundred eight patients with muscle contraction headaches completed a double-blind, randomized, parallel trial in which they took either ibuprofen 400 mg, ibuprofen 800 mg, a spirin 650 mg, or placebo for four successive headaches. Acetaminophen was allowed as a rescue analgesic. Intensity of headache pain was recorded pretreatment and three hours posttreatment. A Pain Intensity Difference (PID) score was calculated from the difference. Patients on ibuprofen (both doses) and aspirin had significantly lower pain scores and higher PID scores at three-hour follow-up than did patients on placebo. Physician's global assessment indicated that both doses of ibuprofen were significantly superior to placebo; aspirin was not. The highest number of side effects occurred with aspirin (26 complaints), followed by placebo (11), ibuprofen 400 mg (3), and ibuprofen 800 mg (2); all were minor. These results suggest that, for the treatment of muscle contraction headache, ibuprofen is significantly more effective than placebo and at least as effective as aspirin. Accepted for Publication: January 10, 1983 | 
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