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Wiley InterScience | ||||||||
  Clinical and Experimental Pharmacology and PhysiologyVolume 10 Issue 5, Pages 535 - 542 Published Online: 28 Jun 2007 Journal compilation © 2010 Blackwell Publishing Asia Pty Ltd
Abstract | References | Full Text: PDF (Size: 436K) | Related Articles | Citation Tracking  PRESYNAPTIC INHIBITION BY SEROTONIN OF CARDIAC SYMPATHETIC TRANSMISSION IN DOGS Copyright 1983 Blackwell Publishing Asia Pty Ltd KEYWORDS cardiac sympathetic transmission • cyproheptadine • desipramine • presynaptic inhibition • serotonin ABSTRACT
1. The effect of serotonin on cardiac sympathetic transmission was investigated in vagotomized and cardiac decentralized dogs. 2. Administration of serotonin in doses of 10-100 μg/kg i.v., during the resting unstimulated state caused tachycardia and pressor responses which were inhibited by cyproheptadine but not by guanethidine. The tachycardia was reduced by a β-adrenoceptor antagonist, bufetolol. 3. Serotonin in doses of 3-100 μg/kg depressed the elevated heart rate during maintained electrical stimulation of the cardiac sympathetic nerves. 4. Cyproheptadine did not antagonize the serotonin-induced depression of the stimulation-elevated heart rate, while desipramine attenuated but did not abolish it. 5. Serotonin did not have a significant effect on the heart rate elevated by maintained infusion of noradrenaline. 6. The present results suggest that serotonin-induced depression of heart rate during sympathetic nerve stimulation is due to presynaptic inhibition by serotonin of cardiac sympathetic transmission which is not mediated via'classic' tryptaminergic receptors. Revision received 27 September 1982 | 
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