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Wiley InterScience | |||||||||
  British Journal of DermatologyVolume 107 Issue 1, Pages 95 - 102 Published Online: 29 Jul 2006 Journal compilation © 2010 British Association of Dermatologists An Official Journal of the British Association of Dermatologists
Abstract | References | Full Text: PDF (Size: 2415K) | Related Articles | Citation Tracking  Hyperpigmentation associated with oral minocycline Copyright 1982 British Association of Dermatologists ABSTRACT
Two patients receiving minocycline developed blue-black pigmentation on the legs. Biopsies from the pigmented areas demonstrated granules containing iron, a pigment with staining properties similar to melanin, and a third pigment which may be a degradation product of minocycline. Electron microscopy showed that some, but not all the granules were membranebound and they were situated mainly within macrophages. Analytical electron microscopy showed that the granules contained iron, sulphur, chlorine and, in one case, calcium. Accepted for publication 22 September 1981 | 
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