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Disulfiram treatment of three patients with nickel dermatitis
Jens Dahl Christensen 1
  1 Department of Dermatology and Venereology, Hvidovre Hospital, University of Copenhagen, 2650 Denmark
Correspondence to  Jens Dahl Christensen, M.D., Smedegaardsparken 25, 4000 Roskilde, Denmark
Copyright Munksgaard 1982
KEYWORDS
Contact dermatitis • disulfiram treatment • nickel

ABSTRACT

Diethyldithiocarbamate chelates nickel and accelerates its excretion in the urine. Disulfiram (Antabuse®) splits into two molecules of sodium diethyldithiocarbamate after absorption. Oral administration of disulfiram tablets starting with 50 mg a day with a gradual increase in dosage to 100 mg not more than twice a day readily cleared the eczema in three patients with severe and long-standing nickel contact dermatitis.


Received February 26, 1981

DIGITAL OBJECT IDENTIFIER (DOI)
10.1111/j.1600-0536.1982.tb04154.x About DOI

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