OSTEOGENIC SARCOMA OF THE NASAL CAVITY IN A CAT: POSTOPERATIVE CONTROL WITH HIGH DOSE-PER-FRACTION RADIATION THERAPY AND METRONIDAZOLE

doi:10.1111/j.1740-8261.1982.tb00704.x

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Wiley InterScience

Veterinary Radiology & Ultrasound

Volume 23 Issue 1, Pages 23 - 26

Published Online: 19 May 2005

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OSTEOGENIC SARCOMA OF THE NASAL CAVITY IN A CAT: POSTOPERATIVE CONTROL WITH HIGH DOSE-PER-FRACTION RADIATION THERAPY AND METRONIDAZOLE

Peter F. Lord, BVSc, FRCVS*, Daniel S. Kapp, MD, PhD*, Anthony Schwartz, DVM, PhD** David T. Morrow, VMD, PhD**

*Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06510 *Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06510

*Department of Surgery, Tufts University School of Veterinary Medicine, Boston, MA 02111

KEYWORDS

Osteogenic sarcoma • radiotherapy • metronidazole • radiosensitizer • cat

ABSTRACT

An 11-year-old Siamese cat with an osteogenic sarcoma of the nasal cavity was treated by partial surgical excision followed by a course of high dose-per-fraction radiation therapy in conjuction with metronidazole, a hypoxic cell sensitizer. Four thousand two hundred rads were delivered to the tumor in 7 weekly fractions. Each treatment was preceded by 6 gm/m² oral metronidazole given 3 hours before irradiation. There were no untoward side effects and the cat was in remission 2 years after treatment.

DIGITAL OBJECT IDENTIFIER (DOI)

10.1111/j.1740-8261.1982.tb00704.x About DOI