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Wiley InterScience | ||||||||
  Clinical and Experimental Pharmacology and PhysiologyVolume 8 Issue 2, Pages 183 - 187 Published Online: 28 Jun 2007 Journal compilation © 2010 Blackwell Publishing Asia Pty Ltd
Abstract | References | Full Text: PDF (Size: 263K) | Related Articles | Citation Tracking  CARDIAC β-ADRENORECEPTORS IN THE THYROXINE-TREATED DOG Copyright 1981 Blackwell Publishing Asia Pty Ltd KEYWORDS
β-adrenoreceptors • cardiac failure • thyrotoxicosis ABSTRACT
1. Myocardial β-adrenoreceptors, assessed in membrane preparations of left ventricle by 2. Left ventricular hypertrophy occurred in response to both aortocaval fistula and thyroxine treatment. Yield of myocardial membrane between the different groups was not significantly different. 3. Binding site concentration (pmol/mg membrane protein) in dogs with aortocaval fistulae was similar to that in normal dogs and was not significantly influenced by the presence or absence of cardiac failure, degree of hypertrophy or duration of fistula. 4. Thyroxine-treated dogs had an increased concentration of binding sites (c. 1.8-fold) compared with both fistula and normal groups, while binding affinities were similar in all groups. 5. The data suggest that β-adrenoreceptor concentrations in myocardium increase as a direct result of thyroid hormone action rather than as a result of secondary haemodynamic changes or ventricular hypertrophy. Received 17 February 1980; revision received 12 August 1980 | 
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