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Wiley InterScience | ||||||||
  Clinical and Experimental Pharmacology and PhysiologyVolume 8 Issue 5, Pages 447 - 450 Published Online: 28 Jun 2007 Journal compilation © 2010 Blackwell Publishing Asia Pty Ltd
Abstract | References | Full Text: PDF (Size: 248K) | Related Articles | Citation Tracking  EFFECT OF CONVERTING ENZYME INHIBITION WITH CAPTOPRIL ON IN VITRO ANGIOTENSIN PRODUCTION IN SHEEP Copyright 1981 Blackwell Publishing Asia Pty Ltd KEYWORDS angiotensin I • angiotensin II • angiotensin III • captopril • sheep ABSTRACT
1. The effect of captopril on in vitro production of angiotensin I (ANG I), [Val5] -angiotensin II ([Vals]-ANG II) and [Val4]-angiotensin III ([Val5]-ANG-(2–8)) in central venous blood taken from sodium-deficient sheep was studied. 2. Captopril enhances in vitro production of ANG I but blocks the in vitro production of [Val5] -ANG II and [Val5] -ANG-(2–8). 3. The production of ANG I in blood is faster than that of [Val5]-ANG II and [Val5] -ANG-(2–8). 4. The half-life of [Val5]-ANG II and [Val5]-ANG-(2–8) in vitro in blood in the presence of captopril was 10 and 14 min, respectively. 5. This in vitro study suggests that the production of [Val5]-ANG II and [Val5] -ANG-(2–8) in blood forms a small part of the total body production of each peptide. | 
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