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Wiley InterScience | |||||||||
  British Journal of DermatologyVolume 101 Issue 2, Pages 171 - 176 Published Online: 29 Jul 2006 Journal compilation © 2010 British Association of Dermatologists An Official Journal of the British Association of Dermatologists
Abstract | References | Full Text: PDF (Size: 1580K) | Related Articles | Citation Tracking  Dermatitis as a side-effect of long-term topical treatment with certain beta-blocking agents Copyright 1979 British Association of Dermatologists ABSTRACT
Three groups of glaucoma patients, treated topically with various beta-blocking agents, were studied for mucocutaneous side-effects of long-term therapy. In five of eleven patients with ocular and/or periocular dermatitis as an adverse reaction to longterm treatment with metoprolol eye drops a dermatitis, reproducible by patch tests with pure metoprolol 3%, was demonstrable. Histopathological examination of positive patch tests examined in three cases showed a picture compatible with a delayed type of hypersensitivity. Four atenolol treated patients showed adverse reactions, but negative patch tests to atenolol were found. In addition new data are reported in favour of cross-reactivity between certain beta-blocking agents. Accepted for publication 27 December 1978 | 
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