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Wiley InterScience | |||||||
  AllergyVolume 34 Issue 2, Pages 121 - 124 Published Online: 28 Apr 2007 Journal compilation © 2010 John Wiley & Sons A/S Published with the European Academy of Allergy and Clinical Immunology (EAACI)
Abstract | References | Full Text: PDF (Size: 260K) | Related Articles | Citation Tracking  Effects of Ketotifen and Clemastine on Passive Transfer of Reaginic Reaction Copyright Munksgaard 1979 KEYWORDS allergy • immediate hypersensitivity • ketotifen • mast cell • reaginic reaction ABSTRACTPassive transfer (PK) tests were performed with a reaginic serum on a recipient reacting with an immediate and a more prolonged reaction when specifically challenged. Both reactions are thought to be mediated by IgE immunology. Ketotifen, a cycloheptathiophene derivative, and clemastine, given to the recipient in maximal clinical doses for 3 days, inhibited the immediate reaction. Ketotifen had a very slight effect also on the prolonged reaction. The results indicate that the in vivo effects of ketotifen in the human system are due not so much to mast cell inhibitory mechanisms, but more to post-release antihistaminic and some anti-inflammatory properties. Accepted for publication 19 September 1978 | 
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