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Wiley InterScience | ||||||||||
  BJOG: An International Journal of Obstetrics & GynaecologyVolume 86 Issue 2, Pages 142 - 147 Published Online: 23 Aug 2005 Journal compilation © 2010 RCOG Published on behalf of the Royal College of Obstetricians and Gynaecologists
Abstract | References | Full Text: PDF (Size: 359K) | Related Articles | Citation Tracking  TREATMENT OF PREMENSTRUAL SYNDROME BY SPIRONOLACTONE Copyright RCOG 1979 BJOG: an International Journal of Obstetrics and Gynaecology ABSTRACT
Spironolactone was given to 28 women in a double blind cross over trial during four menstrual cycles. Hormonal profiles were measured during the first two cycles. Plasma aldosterone was elevated in the premenstrual phase of the cycles but there was no significant difference between symptomatic and asymptomatic groups. The rise in serum progesterone was higher in the symptomatic group during the postovulatory phase. The administration of spironolactone reduced weight and relieved psychological symptoms in more than 80 per cent of the symptomatic group. | 
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