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Wiley InterScience | ||||||||||
  BJOG: An International Journal of Obstetrics & GynaecologyVolume 86 Issue 9, Pages 713 - 716 Published Online: 23 Aug 2005 Journal compilation © 2010 RCOG Published on behalf of the Royal College of Obstetricians and Gynaecologists
Abstract | References | Full Text: PDF (Size: 268K) | Related Articles | Citation Tracking  ENTEROHEPATIC CIRCULATION OF OESTRIOL: A STUDY OF THE EFFECTS OF AMPICILLIN ON PLASMA OESTRIOL LEVELS Copyright RCOG 1979 BJOG: an International Journal of Obstetrics and Gynaecology ABSTRACT
Plasma total oestriol was measured daily before and during ampicillin therapy in five pregnant patients and in eight patients, four of whom were receiving ampicillin, for four days following delivery. Ampicillin caused a fall in plasma oestriol of 25 per cent during the first three days of treatment, thereafter the level remained stable with a lower day-to-day variability than in untreated patients. Ampicillin reduced the plasma half life of total oestriol by 60 per cent. This study illustrates how the re-entry of oestriol from the gut leads to irregular fluctuations in plasma oestriol levels and helps to keep up the plasma concentration of the steroid when inflow from the fetoplacental unit is cut off. | 
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