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Wiley InterScience | ||||||||||
  BJOG: An International Journal of Obstetrics & GynaecologyVolume 85 Issue 4, Pages 251 - 253 Published Online: 23 Aug 2005 Journal compilation © 2010 RCOG Published on behalf of the Royal College of Obstetricians and Gynaecologists
Abstract | References | Full Text: PDF (Size: 214K) | Related Articles | Citation Tracking  THE TREATMENT OF MILD ADRENAL HYPERPLASIA AND ASSOCIATED INFERTILITY WITH PREDNISONE Copyright RCOG 1978 BJOG: an International Journal of Obstetrics and Gynaecology ABSTRACT
Thirty patients with mild post-pubertal adrenal hyperplasia, characterized by raised urinary 17-oxosteroid levels and variable combinations of irregular menses, hirsuties, infertility, and spontaneous abortion, were treated with 2.5 to 10 mg of prednisone per day and all conceived (55 pregnancies). With this treatment, regular, ovulatory cycles occurred immediately in 25 patients, and after two to six months, in the rest. Treatment reduced raised 17-oxosteroid levels to normal and brought about some improvement in hirsuties and acne. Forty-seven pregnancies ended in the birth of liveborn infants; one of these died of prematurity and another had congenital emphysema. One pregnancy was terminated, two were of unknown outcome and five (9.4 per cent) ended in abortion. Before treatment, 20 out of 22 pregnancies (91 per cent) had ended in abortion. | 
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