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Wiley InterScience | ||||||||
  Clinical and Experimental Pharmacology and PhysiologyVolume 4 Issue 2, Pages 121 - 129 Published Online: 28 Jun 2007 Journal compilation © 2010 Blackwell Publishing Asia Pty Ltd
Abstract | References | Full Text: PDF (Size: 578K) | Related Articles | Citation Tracking  CARDIOVASCULAR EFFECTS OF AMITRIPTYLINE IN ANAESTHETIZED DOGS Copyright 1977 Blackwell Publishing Asia Pty Ltd KEYWORDS amitriptyline, • aortic flow, • blood pressure, • coronary flow, • heart rate, • myocardial contractility, • propranolol. ABSTRACT
1. The effect of amitriptyline on cardiovascular variables has been studied in anaesthetized dogs. 2. In small doses (0.25 mg/kg) amitryptyline caused small increases in heart rate, contractility, blood pressure, coronary blood flow and aortic flow. 3. Larger doses produced initial depressant effects on myocardial contractility and rate and blood pressure, which were followed by secondary reflex rises in these measurements. 4. The depressant effects were dose-related and were accompanied by marked increases in coronary flow and smaller increases in aortic flow. 5. The secondary reflex rises in cardiac parameters were abolished by propranolol and that of the blood pressure was much reduced. (Received 21 September 1975) | 
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