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Wiley InterScience | ||||||||||
  BJOG: An International Journal of Obstetrics & GynaecologyVolume 80 Issue 3, Pages 264 - 270 Published Online: 23 Aug 2005 Journal compilation © 2010 RCOG Published on behalf of the Royal College of Obstetricians and Gynaecologists
Abstract | References | Full Text: PDF (Size: 675K) | Related Articles | Citation Tracking  KARYOTYPIC PROFILES OF WOMEN AFTER CLOMIPHENE CITRATE THERAPY * Current address: Department of Obstetrics and Gynecology, Boston City Hospital, and Boston University School of Medicine. Copyright RCOG 1973 BJOG: an International Journal of Obstetrics and Gynaecology ABSTRACT
Cytogenetic studies were made before and after clomiphene therapy on endometrial tissue obtained from seven patients with anovulation. In a further six subjects, endometrial karyotypic patterns were studied before drug administration. Statistical analysis of a large number of cells revealed that after treatment there was an increase in heteroploidy as well as in chromatid lesions and aberrations. The biological significance of these findings remains uncertain. They may reflect the action of the compound at the cellular level and could thus explain the occurrence of persistent infertility despite the successful induction of ovulation. | 
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