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Wiley InterScience | ||||||||
  Alcoholism: Clinical and Experimental ResearchVolume 20 Issue 5, Pages 853 - 858 Published Online: 22 Jun 2007 © 2010 Research Society on Alcoholism
Abstract | References | Full Text: PDF (Size: 694K) | Related Articles | Citation Tracking  Efficacy of Buspirone in Alcohol Dependence: A Review This study was supported by Bristol Myers Squibb and the Douglas Hospital Research Center. Copyright 1996 The Research Society on Alcoholism KEYWORDS Buspirone • Alcoholism • Treatment • Efficacy • Metaanalysis ABSTRACTThe five published controlled studies on the effects of buspirone in alcoholism treatment are reviewed. They have been conducted mostly in alcoholics with comorbid anxiety. Significant differences in favor of the medication were observed in several psychopathological measures (anxiety, depression, hostility, interpersonal sensitivity, and global psychopathology). In only two studies were alcohol craving and consumption found influenced. Metaanalysis showed positive effects of buspirone on treatment retention, as well as on anxiety. It can be concluded that the main effect of buspirone in the treatment of alcoholism is not on ethanol consumption pew se, but on associated psychopathological symptoms. A favorable safety profile and a lack of interaction with alcohol make buspirone a useful pharmacological adjunct in the treatment of alcoholism. Received for publication October 16, 1995; accepted March 22, 1996 | 
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