Analysis of the antifungal activity of ketoconazole, zinc pyrithione, and ciclopirox olamine against Pityrosporum ouale. A diffusion assay for cultures in solid media

doi:10.1111/j.1468-3083.1996.tb00552.x

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Wiley InterScience

Journal of the European Academy of Dermatology and Venereology

Volume 7 Issue 1, Pages 26 - 29

Published Online: 28 Jul 2006

Published on behalf of the European Academy of Dermatology and Venereology

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Analysis of the antifungal activity of ketoconazole, zinc pyrithione, and ciclopirox olamine against Pityrosporum ouale. A diffusion assay for cultures in solid media

Luis Squiquera ^a, *, Lilian Plotkin ^b , Irina Mathov ^b , Ricardo Galimberti ^a , Juliana Leoni ^b

^a IDEHU (Department of Immunology, University of Buenos Aires), Junin 956, 4th floor, 1113 Buenos Aires, Argentina ^b Department of Dermatology, Hospital Italiano de Buenos Aires, Buenos Aires.

*Corresponding author.

KEYWORDS

Pityrosporum ovale • Antifungals • Ketoconazole • Octopirox • Zinc pyrithione

ABSTRACT

Background

Recently dandruff has been associated with a local increment in the number of Pityrosporum yeasts. Due to this fact, several anti-dandruff shampoos containing antifungals have been marketed.

Objective

We studied the sensitivity of Pityrosporum ovale (PO) to three different groups of antimycotics (ketoconazole, Zn pyrithione, and ciclopirox olamine).

Methods /Results

The drugs were tested by an inhibition assay in solid medium. Ketoconazole proved to be the most effective drug in inhibiting PO growth in a dose-dependent fashion. The results of our evaluation revealed that the inhibitory effects of the drugs were ketoconazole > Zn pyrithione > ciclopirox olamine.

Conclusion

We postulate that the diffusion assay is a reliable medium for evaluating the effectiveness of antifungals contained in anti-dandruff shampoos.

DIGITAL OBJECT IDENTIFIER (DOI)

10.1111/j.1468-3083.1996.tb00552.x About DOI