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Wiley InterScience | |||||||||||||||||
  Annals of Human GeneticsVolume 72 Issue 4, Pages 535 - 546 Published Online: 30 May 2008 Journal compilation © 2010 Blackwell Publishing Ltd/University College London
Abstract | References | Full Text: HTML, PDF (Size: 605K) | Related Articles | Citation Tracking  Using Population Mixtures to Optimize the Utility of Genomic Databases: Linkage Disequilibrium and Association Study Design in India Copyright Journal compilation © 2008 University College London KEYWORDS association mapping • Bengali • Indian population • portability • single-nucleotide polymorphism • Tamil ABSTRACTWhen performing association studies in populations that have not been the focus of large-scale investigations of haplotype variation, it is often helpful to rely on genomic databases in other populations for study design and analysis – such as in the selection of tag SNPs and in the imputation of missing genotypes. One way of improving the use of these databases is to rely on a mixture of database samples that is similar to the population of interest, rather than using the single most similar database sample. We demonstrate the effectiveness of the mixture approach in the application of African, European, and East Asian HapMap samples for tag SNP selection in populations from India, a genetically intermediate region underrepresented in genomic studies of haplotype variation.
Received: 26 November 2007 | 
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