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Wiley InterScience | ||||||||
  Acta Anaesthesiologica ScandinavicaVolume 48 Issue 5, Pages 625 - 630 Published Online: 11 Mar 2004 Journal compilation © 2010 The Acta Anaesthesiologica Scandinavica Foundation Official Publication of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine
Abstract | References | Full Text: HTML, PDF (Size: 138K) | Related Articles | Citation Tracking  The effect of promethazine on postoperative pain: a comparison of preoperative, postoperative, and placebo administration in patients following total abdominal hysterectomy The study was partly supported by grants from Tsou's Medical Research Foundation and Kaohsiung Veterans General Hospital (VGHKS92-04). The preliminary data were presented at the 7th Biennial Congress of Asian & Oceanic Society of Regional Anaesthesia and Pain medicine. Copyright Acta Anaesthesiol Scand, 2004 KEYWORDS Analgesics • opioid • morphine • histamine receptor antagonist • promethazine • pain • postoperative ABSTRACTBackground: Histamine receptors are involved in the development of inflammatory pain and hyperalgesia, and the use of antihistamines is advocated as an alternative for pain therapy and treatment of postoperative nausea and vomiting. We investigated the influence of timing of promethazine administration on postoperative pain outcomes. Methods: Ninety female patients undergoing total abdominal hysterectomy were randomly divided into three groups. All individuals received infusions of promethazine and normal saline before anaesthesia induction, and postoperatively the Pre group received promethazine 0.1 mg kg Results: Postoperative morphine usage was significantly lower in the Pre group (24.1 ± 3.9 mg) relative to the Post (30.0 ± 4.6 mg) and Control groups (32.1 ± 4.8 mg) during the first 24 h postoperatively (P<0.05). The number and incidence of patients suffering from postoperative nausea in the first 24 h was six (21%), seven (23%), and 15 (47%) in the Pre, Post, and Control groups, respectively (P<0.05). The number and incidence of patients vomiting in the first 24 h was three (10%), two (7%), and 10 (32%) in the Pre, Post, and Control groups, respectively (P<0.05). The number of patients asking for rescue antiemetic in the first 24 h was one (3%), two (7%), and seven (22%) in the Pre, Post, and Control groups, respectively (P<0.05). Conclusions: Our results suggest that preoperative administration of promethazine 0.1 mg kg Accepted for publication 1 January 2004 | 
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