Effects of insulin pump vs. injection treatment on quality of life and impact of disease in children with type 1 diabetes mellitus in a randomized, prospective comparison

doi:10.1111/j.1399-5448.2008.00396.x

If you are seeing this message, you may be experiencing temporary network problems. Please wait a few minutes and refresh the page. If the problem persists, you may wish to report it to your local Network Manager.

It is also possible that your web browser is not configured or not able to display style sheets. In this case, although the visual presentation will be degraded, the site should continue to be functional. We recommend using the latest version of Microsoft or Mozilla web browser to help minimise these problems.

Wiley InterScience

Pediatric Diabetes

Volume 9 Issue 4pt1, Pages 291 - 296

Published Online: 7 May 2008

Official publication of ISPAD

Go to Society Site

< Previous Abstract | Next Abstract >

Save Article to My Profile Download Citation Request Permissions

Abstract | References | Full Text: HTML, PDF (Size: 94K) | Related Articles | Citation Tracking

Original Article

Effects of insulin pump vs. injection treatment on quality of life and impact of disease in children with type 1 diabetes mellitus in a randomized, prospective comparison

Roos Nuboer ^a , Gerard JJM Borsboom ^b , Jan Age Zoethout ^a , Hans M Koot ^c Jan Bruining ^a

^a Department of Pediatrics, Erasmus MC/Sophia Children's Hospital, Rotterdam, The Netherlands; ^bDepartment of Public Health, Erasmus MC, Rotterdam, The Netherlands; and ^cDepartment of Developmental Psychology, VU University, Amsterdam, The Netherlands

Correspondence to R Nuboer, MD
Division of Pediatrics
MeanderMC/Elisabeth Hospital
PO Box 1502
3800 BM Amersfoort
The Netherlands.
Tel: +31338504580;
fax: +031338504893;
e-mail: r.nuboer@meandermc.nl

KEYWORDS

child • diabetes mellitus type 1 • insulin pump • quality of life

Nuboer R, Borsboom GJJM, Zoethout JA, Koot HM, Bruining J. Effects of insulin pump vs. injection treatment on quality of life and impact of disease in children with type 1 diabetes mellitus in a randomized, prospective comparison.
Pediatric Diabetes 2008: 9 (Part I): 291–296.

ABSTRACT

Objective: Effects of pump treatment vs. four times daily injections were explored in children with diabetes with regard to quality of life and impact of disease as well as adverse effects and parameters of metabolic control.

Methods: An open, parallel, randomized controlled prospective comparative study lasting 14 months was completed by 38 type 1 children with diabetes (age 4–16 yr) following a 3.5-months run-in phase. Standardized quality-of-life Pediatric Quality of life Inventory (PedsQL) and impact of disease scores were obtained every 3.5 months as well as regular medical parameters. Parallel treatment group data and longitudinal within-patient data were analysed for each treatment modality.

Results: Within-patient comparisons of the two treatment modalities showed significant improvement in PedsQL and impact scores after pump treatment. Treatment group comparisons did not show significant improvement. Pump treatment resulted in decreased symptomatic hypoglycaemia and lowered haemoglobin A1c by 0.22% after run in.

Conclusions: Within-patient comparison suggests that metabolic control, frequency of severe hypoglycaemia (a threefold decrease), quality of life and impact of disease scores are improved by pump treatment in comparison to regular treatment with four daily insulin injections.

Submitted 17 July 2007. Accepted for publication 26 January 2008

DIGITAL OBJECT IDENTIFIER (DOI)

10.1111/j.1399-5448.2008.00396.x About DOI