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Wiley InterScience | ||
  Acta Obstetricia et Gynecologica ScandinavicaVolume 80 Issue 11, Pages 1056 - 1061 Published Online: 28 Jun 2008 Acta Obstet Gynecol Scand, 2005
Abstract | References | Full Text: HTML, PDF (Size: 66K) | Related Articles | Citation Tracking  Early pregnancy termination with mifepristone and misoprostol in Norway Copyright Acta Obstet Gynecol Scand 2001 KEYWORDS antiprogestin • pregnacy termination • prostaglandin analog ABSTRACTObjectives. Medical abortion was first introduced in Norway in April 1998. The aims of this study were to assess the efficacy, side effects, and acceptability of medical abortion using mifepristone orally and misoprostol vaginally in a Norwegian population. Design. The study included the first 226 pregnant women with gestational age of <63 days who requested nonsurgical abortion during the first year in the first Norwegian hospital using this regimen. Methods. All women received a single dose of mifepristone 600 mg orally, followed at 48 hours by 800 μg misoprostol vaginally. Treatment outcome and complications were the principal outcome measures. We also measured the rates of side effects such as abdominal pain and bleeding and the women's acceptability of treatment. Results. Abortion was successful in 95%, surgical evacuation became necessary in 4%, and the pregnancy continued in one woman. During the study period the method was chosen by 23% of those requesting abortion before 63 days amenorrhea; 80% would use the method again; 81% would recommend it to a friend; in retrospect, 69% would not have been willing to be randomly allocated to either a medical or a surgical method. Conclusions. The combination of orally administrated mifepristone and vaginally administrated misoprostol is an abortion method that is both effective and safe, has few side effects and is well accepted by Norwegian women. Submitted 9 February, 2001 |  |
