Multimodal Hyperspectral Imaging for the Noninvasive Diagnosis of Cervical Neoplasia

doi:10.1046/j.1526-0976.2001.005002065.x

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Wiley InterScience

Journal of Lower Genital Tract Disease

Volume 5 Issue 2, Pages 65 - 72

Published Online: 21 Dec 2001

2002 The American Society for Colposcopy and Cervical Pathology

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Multimodal Hyperspectral Imaging for the Noninvasive Diagnosis of Cervical Neoplasia

Daron G. Ferris, MD,* Raymond A. Lawhead, MD, ^‡ Eileen D. Dickman, PhD, MBA,* Nina Holtzapple, MD, ^† Jill A. Miller, MD,* Stephanie Grogan, MD, ^‡ Shabbir Bambot, PhD, ^§ Anant Agrawal, MS, ^§ Mark L. Faupel, PhD ^§

*The Departments of Family Medicine and
^† Obstetrics and Gynecology, the Medical College of Georgia, Augusta, ^‡ Atlanta Medical Center, Atlanta, and
^§ SpectRx, Inc., Norcross, Georgia

Correspondence to Reprint requests to: Daron G. Ferris, MD, Medical College of Georgia, 1423 Harper Street, HH-105, Augusta, Georgia 30912

KEYWORDS

cervical neoplasia • noninvasive diagnosis • Multimodal Hyperspectral Imaging • Papanicolaou smear

ABSTRACT

Abstract

Objective. To determine the ability of Multimodal Hyperspectral Imaging (MHI) to noninvasively detect, localize and diagnose cervical neoplasia.

Materials and Methods. The cervical epithelium was interrogated by MHI using tissue fluorescence and reflectance measurements after the probe was placed on the ectocervix. A Papanicolaou smear was taken, and a colposcopic examination was performed and cervical histologic specimens were collected, when indicated. MHI and Pap smear sensitivity and specificity data were compared with colposcopic and histologic results.

Results. Nineteen patients had CIN2 or higher, 30 had CIN1, 34 had benign cellular changes or metaplasia, and 28 were normal by both Pap smear and colposcopic examination. At equal specificity (70%) for both tests, the sensitivity of MHI was 97%, compared to 72% for the Pap smear.

Conclusion. MHI detected cervical cancer precursors at a rate greater than that obtained by a simultaneously collected Pap smear.

DIGITAL OBJECT IDENTIFIER (DOI)

10.1046/j.1526-0976.2001.005002065.x About DOI