A Randomized Controlled Trial of Metronidazole Vaginal Cream in the Treatment of Papanicolaou Smears Showing Atypical Squamous Cells of Undetermined Significance (ASCUS)

doi:10.1046/j.1526-0976.2001.54006.x

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Wiley InterScience

Journal of Lower Genital Tract Disease

Volume 5 Issue 4, Pages 219 - 222

Published Online: 21 Dec 2001

2002 The American Society for Colposcopy and Cervical Pathology

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A Randomized Controlled Trial of Metronidazole Vaginal Cream in the Treatment of Papanicolaou Smears Showing Atypical Squamous Cells of Undetermined Significance (ASCUS)

L. Chesney Thompson, MD , Patricia O'Connor , Rncnp , and Ronald S. Gibbs, MD

Department of Obstetrics and Gynecology, University of Colorado,
Health Sciences Center, Denver, Colorado

Correspondence to Reprint requests to: L. Chesney Thompson, MD, 4200 E. Ninth Ave, Campus Box B-198, Denver, CO 80262.

KEYWORDS

atypical squamous cells of undetermined significance • ASCUS • bacterial vaginosis • metronidazole

ABSTRACT

Abstract

Objective. To compare topical metronidazole gel vs. placebo to assess resolution to normal in subsequent Pap smears of patients with ASCUS.

Materials and Methods. Patients with ASCUS pap smears were randomized to metronidazole or placebo. Resolution of ASCUS vs. persistence, or progression, was the endpoint. A subanalysis stratified patients for bacterial vaginosis (BV) to determine if this population responded differently. Discrete variables were compared using chi-square analysis.

Results. Forty-nine patients received metronidazole and 52 received placebo. The rate of resolution in the placebo group were 60%, and 67% in the metronidazole group. With BV, the rate of resolution in the placebo group was 67%, and 70% in the metronidazole group. These were not significantly different.

Conclusions. Treatment of ASCUS Pap smears using topical metronidazole did not demonstrate a significant increase in the rate of resolution in subsequent Pap smears in the overall group nor in a subgroup with BV.

DIGITAL OBJECT IDENTIFIER (DOI)

10.1046/j.1526-0976.2001.54006.x About DOI