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Wiley InterScience | |||||
  Diabetic MedicineVolume 16 Issue 2, Pages 164 - 167 Published Online: 24 Dec 2001 Journal compilation © 2010 Diabetes UK
Abstract | References | Full Text: HTML, | Related Articles | Citation Tracking  Reversal of corticosteroid-induced diabetes mellitis with supplemental chromium Copyright 1999 British Diabetic Association KEYWORDS chromium • corticosteroids • diabetes mellitis • glucose • insulin • steroid-induced diabetes mellitis • trace elements ABSTRACTSummaryAims To determine if the stress of corticosteroid treatment increases chromium (Cr) losses and if corticosteroid-induced diabetes (steroid diabetes) can be reversed by supplemental chromium. Methods The effects of corticosteroid treatment on chromium losses of 13 patients 2 days prior to steroid administration and the first 3 days following treatment were determined. Since steroid-induced diabetes was associated with increased chromium losses and insufficient dietary chromium is associated with glucose intolerance and diabetes, we treated three patients with steroid-induced diabetes with 600 μg per day of chromium as chromium picolinate. Results Urinary chromium losses following corticosteroid treatment increased from 155 ± 28 ng/d before corticosteroid treatment to 244 ± 33 ng/d in the first 3 days following treatment. Chromium supplementation of patients with steroid-induced diabetes resulted in decreases in fasting blood glucose values from greater than 13.9 mmol/l (250 mg/dl) to less than 8.3 mmol/l (150 mg/dl). Hypoglycaemic drugs were also reduced 50% in all patients when given supplemental chromium. Conclusions These data demonstrate that corticosteroid treatment increases chromium losses and that steroid-induced diabetes can be reversed by chromium supplementation. Follow-up, double-blind studies are needed to confirm these observations. Diabet. Med. 16, 164–167 (1999) Received 20 May 1998; revised 3 August 1998; accepted 18 August 1998 | 
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