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Wiley InterScience


Fundamental & Clinical Pharmacology

Fundamental & Clinical Pharmacology

Volume 15 Issue 1, Pages 61 - 63

Published Online: 7 Jul 2008

Journal compilation © 2010 Société Française de Pharmacologie et de Thérapeutique



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Endoscopic evaluation of the gastrotolerance of short-term antalgic treatment with low dose k-diclofenac: a comparison of ibuprofen and aspirin
Isabelle Mahé a *, Stéphane Mouly a , Emmanuel Mahé b , Myriam Diemer a , Anne-Laure Knellwolf a , Guy Simoneau a , Charles Caulin a & Jean-François Bergmann a
  a Unité de Recherches Thérapeutiques, Hôpital Lariboisière, 2 rue Ambroise Paré, 75010 Paris, France   b Service Dermatologie, Hôpital Bichat Claude Bernard, 46 rue Henri Huchard, 75018 Paris, France
Correspondence to: Isabelle Mahé
Copyright Societe Francaise de Pharmacologie
KEYWORDS
aspirin • gastro-intestinal damage • ibuprofen

ABSTRACT

In a short-term gastro-duodenal endoscopic study in 12 healthy volunteers, the gastrotoxicity was not different after intake of diclofenac-K 12.5 mg (0.33) or ibuprofen 200 mg (0.42, P=0.66) but significantly higher after aspirin 500 mg (2.67, P=0.002).


DIGITAL OBJECT IDENTIFIER (DOI)
10.1111/j.1472-8206.2001.00004.x About DOI

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