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Wiley InterScience | ||||||||
  British Journal of HaematologyVolume 16 Issue 1, Pages 31 - 38 Published Online: 12 Mar 2008 © 2010 Blackwell Publishing Ltd The Official Journal of the British Society for Haematology
Abstract | References | Full Text: PDF (Size: 419K) | Related Articles | Citation Tracking  The Interpretation of Prothrombin Results: A National Survey Copyright 1969 Blackwell Publishing Ltd ABSTRACTThe practical value of a formula for the interpretation of prothrombin time results has been studied in a national survey incorporating 132 of the hospital centres in our reference thromboplastin scheme. In this formula the 'equivalent ratio' is used to calculate the 'Index of Anticoagulation' in an attempt to provide a uniform scale of measurement for all hospitals. In our survey the calculated results using the formula were compared with the actual observed values. Only 15 hospitals were able to calculate the 'Index of Anticoagulation'; of these only nine sent a complete set of results. Incomplete schedules were interpreted by us. The survey showed that the value of the formula was least with commercial reagents, but even with human brain extracts the difference between calculated and observed results was considerable. From this study it is concluded that the term 'equivalent ratio' is of considerable value in measuring the sensitivity of a tissue extract thromboplastin, but nothing is to be gained from the vise of the formula for the 'Index of Anticoagulation'in the Manchester scheme for providing uniform anticoagulant treatment. | 
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