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Wiley InterScience

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Mathematical Modelling in Neuroendocrinology
G. Leng and D. J. MacGregor
Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK.
Correspondence to Prof. Gareth Leng, School of Biomedical Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK (e-mail: gareth.leng@ed.ac.uk).
Copyright Journal compilation © 2008 Blackwell Publishing
KEYWORDS
modelling • complexity • neuroendocrinology • emergence • functionalism

ABSTRACT

In neuroendocrinology, mathematical modelling is about formalising our understanding of the behaviour of the complex biological systems with which we deal. Formulating our explanations mathematically ensures their logical consistency, and makes them open to structured analysis; it is a stringent test of their intellectual coherence. In addition, however, modellers are seeking to extend our understanding in new ways, by seeking novel, simple explanations for complex behaviour. Here we discuss some styles of modelling as they have been applied to neuroendocrine systems, and discuss some of their strengths and limitations.


Received: 22 February 2008, revised 18 March 2008, accepted 19 March 2008

DIGITAL OBJECT IDENTIFIER (DOI)
10.1111/j.1365-2826.2008.01722.x About DOI

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