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The clinical pharmacology of oxazepam
M. H. LADER 1
  1 Institute of Psychiatry, Department of Psychiatry (Head: Sir Denis Hill), London, England
Copyright 1978 Blackwell Publishing Ltd
KEYWORDS
Benzodiazepines • oxazepam • psychology • clinical • aggression • drug dependence.

ABSTRACT

The benzodiazepines have been available now for about 1.5 years but new aspects of their actions are being elucidated all the time. Oxazepani has a short half-life and inactive metabolites and therefore differs from most other benzodiazepines. Some aspects of its clinical pharmacology are reviewed in outline. Firstly, the effects of the drug on psychological functioning is discussed. Next, the controversy regarding benzodiazepinea and aggression is examined. Oxazepam appears exceptional here in that it is not associated with paradoxical release of aggression in patients. Finally, the ethical implications of the widespread use of these drugs is commented on, and the problem of dependence, physical and psychological, discussed. It appears that oxazepam is less likely than other benzodiazepines to induce dependence.


DIGITAL OBJECT IDENTIFIER (DOI)
10.1111/j.1600-0447.1978.tb02391.x About DOI

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