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Wiley InterScience | ||||
  AddictionVolume 94 Issue 5, Pages 665 - 674 Published Online: 3 May 2002 Journal compilation © 2010 Society for the Study of Addiction Published on behalf of the Society for the Study of Addiction
Abstract | Full Text: PDF (Size: 139K) | Related Articles | Citation Tracking  Additional methadone increases craving for heroin: a double-blind, placebo-controlled study of chronic opiate users receiving methadone substitution treatment Copyright Society for the Study of Addiction to Alcohol and Other Drugs This page may not be reproduced without further permission ABSTRACTAims. To assess the acute-on-chronic effects of methadone on drug craving, mood and cognitive and psychomotor functioning in patients on long-term methadone substitution treatment. Design and participants. A double-blind, cross-over design was used to compare the effects of a 33% increase in patient's daily dosage of methadone with a matched placebo linctus. Eighteen patients completed the study; all were assessed pre- and post-drug on two separate testing days. Findings. Methadone significantly increased both positive craving (expected positive effects) and negative craving (expected relief of withdrawal discomfort) for heroin. Patients were unable to distinguish between methadone and placebo treatments. No differences between treatments emerged in cognitive or psychomotor effects. In terms of mood, patients were more alert and more contented following placebo than following methadone. Conclusions. Additional methadone may "prime" cravings for heroin in methadone substitution patients. | 
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