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Wiley InterScience | ||||||||||||||
  Journal of Applied MicrobiologyVolume 105 Issue 5, Pages 1361 - 1371 Published Online: 5 Sep 2008 Journal compilation © 2010 The Society for Applied Microbiology The Official Journals of the Society for Applied Microbiology
Abstract | References | Full Text: HTML, PDF (Size: 1151K) | Related Articles | Citation Tracking  ORIGINAL ARTICLE Dose–response model for Burkholderia pseudomallei (melioidosis) Copyright Journal compilation © 2008 The Society for Applied Microbiology KEYWORDS BALB/c mice •
Burkholderia mallei
•
Burkholderia pseudomallei
• C57BL/6 mice • diabetic rats • dose–response models • melioidosis ABSTRACTAims: The objective of this study was development of a dose–response model for exposure to Burkholderia pseudomallei in different animal hosts and analysis of the results. The data sets with which the model was developed were taken from the open literature. Methods and Results: All data sets were initially tested for a trend between dose and outcome using the Cochran–Armitage test. Only data showing a statistically significant trend were subjected to further analysis (fitting with parametric dose–response relationships). Dose–response relationships (exponential, beta-Poisson and log-probit) were fit to data using the method of maximum likelihood estimation. Conclusions: Dose–response analysis of BALB/c mice, C57BL/6 mice, guinea pigs and diabetic rats showed that BALB/c mice exposed intranasally (i.n.) and guinea pigs exposed intraperitoneally (i.p.) are significantly more sensitive to B. pseudomallei than C57BL/6 mice exposed i.n. and diabetic rats exposed i.p. Significance and Impact of the Study: The results confirmed the findings of a study of outbreak data that the diabetic population is more susceptible to infection with B. pseudomallei than the general population. The low dose prediction from best fit dose–response models can be used to draw guidelines for public health decision making processes, including consideration of sensitive subpopulations. 2008/0055: received 10 January 2008, revised 14 March 2008 and accepted 29 March 2008 | 
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