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Wiley InterScience | |||||||||
  Insect Molecular BiologyVolume 18 Issue 1, Pages 71 - 75 Published Online: 19 Jan 2009 Journal compilation © 2009 Royal Entomological Society
Abstract | References | Full Text: HTML, PDF (Size: 213K) | Supporting Information | Related Articles | Citation Tracking  Lipopolysaccharide elicits expression of immune-related genes in the silkworm, Bombyx mori Copyright Journal compilation © 2009 Royal Entomological Society KEYWORDS insect immunity •
Bombyx mori
• antimicrobial peptide gene • lipopolysaccharide ABSTRACTLipopolysaccharide (LPS), a major cell wall component of Gram-negative bacteria, was found to be unable to activate immune-related genes in Drosophila melanogaster. In contrast, highly purified LPS elicited immune-related gene expression in the fat body of Bombyx mori. However, the level of activation by highly purified LPS was lower than crude LPS and peptidoglycan. Furthermore, synthetic lipid A also activated these genes, suggesting that B. mori possesses unknown signal pathways to activate immune-related genes by LPS. Up-regulation of antimicrobial peptide genes by highly purified LPS was not confirmed in the immune-responsive cell line, NIAS-Bm-aff3, suggesting that some factors necessary for signal transduction activated by LPS are deficient in this cell line. | 
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