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Nutrition in Clinical Care
Metabolic osteopathy in celiac disease: importance of a gluten-free diet
Vanessa D Capriles 1 , Ligia A Martini 1 , and José Alfredo G Arêas 1
  1 Nutrition Department, School of Public Health, São Paulo University, São Paulo, Brazil
Correspondence to   LA Martini, Nutrition Department, School of Public Health, São Paulo University, Av. Dr. Arnaldo 715, CEP 01246-904, São Paulo – SP, Brazil. E-mail: lmartini@usp.br, Phone: +55-11-30617701, Fax: +55-11-30617705.
Copyright © 2009 International Life Sciences Institute
KEYWORDS
bone mineral density • celiac disease • gluten-free diet

ABSTRACT

Reduced bone mineral density (BMD) is frequently found in individuals with untreated celiac disease (CD), possibly due to calcium and vitamin D malabsorption, release of pro-inflammatory cytokines, and misbalanced bone remodeling. A gluten-free diet (GFD) promotes a rapid increase in BMD that leads to complete recovery of bone mineralization in children. Children may attain normal peak bone mass if the diagnosis is made and treatment is given before puberty, thereby preventing osteoporosis in later life. A GFD improves, but rarely normalizes, BMD in patients diagnosed with CD in adulthood. In some cases, nutritional supplementation may be necessary. More information on therapeutic alternatives is needed.


DIGITAL OBJECT IDENTIFIER (DOI)
10.1111/j.1753-4887.2009.00232.x About DOI

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