The plaque inhibitory effect of a CPC mouthrinse in a 3-day plaque accumulation model – a cross-over study

To cite this article:
Int J Dent Hygiene
DOI: 10.1111/j.1601-5037.2009.00421.x
Versteeg PA, Rosema NAM, Hoenderdos NL, Slot DE, van der Weijden GA. The plaque inhibitory effect of a CPC mouthrinse in a 3-day plaque accumulation model – A cross-over study.

ABSTRACT

 Abstract: 

Objective: To test the plaque inhibitory effect of an experimental 0.07% cetylpyridinium chloride (CPC) mouthrinse in a 3-day plaque accumulation model in a cross-over design.

Material and Methods: A total of 30 subjects (non-dental students), ≥18 years of age, were randomly assigned to use one of three different mouthrinses three times a day. After 3 days, the subjects returned for the clinical assessments and received a questionnaire to evaluate their attitude towards the product used by them. The cross-over procedure was repeated twice to have all subjects use all products.

Results: A total of 29 subjects completed the protocol and this resulted in a statistically significant difference between the three groups (P < 0.001) with regard to plaque scores. Over three sessions, the mean plaque scores were 2.17 for the control product, 1.14 for the CPC group and 1.12 for the 0.1% Hexetidine product (positive control). Results of the questionnaire show that, compared with hexetidine, the taste of the CPC was appreciated better, and less oral sensations were observed following rinsing.

Conclusion: The CPC mouthrinse proved to be effective in inhibiting 'de novo' plaque formation to an extent similar to that of a 0.1% hexetidine product. Compared with hexetidine, the taste of the CPC was appreciated better and less oral sensations were observed following rinsing.