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Wiley InterScience | ||||
  Journal der Deutschen Dermatologischen GesellschaftEarly View (Articles online in advance of print)Published Online: 2 Nov 2009 Journal compilation © Blackwell Verlag GmbH, Berlin
Abstract | References | Full Text: HTML, PDF (Size: 1130K) | Related Articles | Citation Tracking  Topical treatment of actinic keratoses with low-dose 5-fluorouracil in combination with salicylic acid – pilot study Max
Schlaak
Correspondence to Department of Dermatology and Venereology Uniklinik Köln, University hospital Cologne Kerpener Str. 62 D-50924 Cologne, Germany E-mail: max.schlaak@uk-koeln.de Copyright Journal compilation © Blackwell Verlag GmbH, Berlin KEYWORDS actinic keratoses • 5-FU • salicylic acid • topical treatment ABSTRACTBackground: Actinic keratoses (AK) are carcinomas in situ and can progress to invasive squamous cell carcinomas. Treatment of actinic keratoses can be achieved by physical ablation, chemotherapeutic agents, immunomodulators or photodynamic therapy. Patients and Methods: We conducted a proof of concept study with 15 patients. Overall 66 actinic keratoses were treated with 5-FU (0.5 %) and salicylic acid (10 %) for 4 weeks (3 times per week). Results: After 12 weeks complete response of 47 AK (77 %), partial response of 13 AK (21 %) and non-response of 1 AK (2 %) were achieved. Conclusions: Treatment was well tolerated and efficient. Submitted: 14.7.2009 | Accepted: 30.9.2009 | 
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