Topiramate overdose: A case report of a patient with extremely high topiramate serum concentrations and nonconvulsive status epilepticus

doi:10.1111/j.1528-1167.2009.02395.x

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Wiley InterScience

Epilepsia

Early View (Articles online in advance of print)

Published Online: 3 Nov 2009

Published on behalf of the International League Against Epilepsy (ILAE)

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BRIEF COMMUNICATION

Topiramate overdose: A case report of a patient with extremely high topiramate serum concentrations and nonconvulsive status epilepticus

*Christian Brandt, †Heike Elsner, *Nora Füratsch, *Matthias Hoppe, *Esther Nieder, ‡Bernhard Rambeck, *Alois Ebner, and ‡Theodor W. May

*Bethel Epilepsy Centre, Department of General Epileptology, Bielefeld, Germany ; †Vocational Training Centre, Bielefeld, Germany ; and ‡Pharmacological Laboratory, Society for Epilepsy Research, Bielefeld, Germany

Address correspondence to Prof. Dr. Theodor W. May, Pharmacological Laboratory, Society for Epilepsy Research, Maraweg 13, D-33617 Bielefeld, Germany. E-mail: Theodor.May@evkb.de

KEYWORDS

Topiramate • Overdose • Intoxication • Nonconvulsive status epilepticus • Suicide attempt

ABSTRACT

We report the case of a 21-year-old man with idiopathic generalized epilepsy who ingested about 8,000 mg of topiramate (TPM) in a suicide attempt. On admission to the hospital he had a nonconvulsive status epilepticus and received 4 mg lorazepam i.v. He recovered rapidly despite an initial TPM concentration of 144.6 μg/ml. To our knowledge, this is the first report of a patient who survived such a high TPM concentration. The case indicates that nonconvulsive status epilepticus could be a manifestation of TPM intoxication.

Accepted September 9, 2009; Early View publication Xxxxx xx, 200x.

DIGITAL OBJECT IDENTIFIER (DOI)

10.1111/j.1528-1167.2009.02395.x About DOI