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  Published on behalf of the American Cancer Society Journal Home | Society | News Product Information | Editorial Board | For Authors | Access Policy | Subscribe | Advertise | Contact | Online Submission Early View(Articles online in advance of print)Original ArticlesDisease SiteGastrointestinal DiseaseReduced incidence of infusion-related reactions in metastatic colorectal cancer during treatment with cetuximab plus irinotecan with combined corticosteroid and antihistamine premedication (p NA) The current article presents a post hoc analysis of data from a European prelicense study of a monoclonal antibody, Erbitux (cetuximab), where the incidence of infusion-related reactions according to the type of prophylactic premedication administered before cetuximab infusion was investigated. Patients who received both an antihistamine and a corticosteroid had a reduced frequency of such reactions compared with those who received antihistamine alone, and the type of premedication did not impact treatment efficacy. Abstract
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 Hematologic MalignanciesWhich AML subsets benefit from leukemic cell priming during chemotherapy? Long-term analysis of the ALFA-9802 GM-CSF study (p NA) Sensitization of leukemic cells and their progenitors by granulocytic hematopoietic growth factors appears as a plausible strategy for improving the outcome of younger patients with newly diagnosed acute myeloid leukemia. Patients with poor-prognosis fms-like tyrosine kinase-3 internal duplications or mixed-lineage leukemia genen rearrangement might be a good target population to further investigate priming strategies. Abstract
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DisciplineDisparities ResearchRacial and insurance disparities in the receipt of transplant among patients with hepatocellular carcinoma (p NA) Black patients and Medicaid recipients with hepatocellular carcinoma are much less likely than white and privately insured patients to receive a liver transplant. Those who did not receive a transplant were 3 times as likely as transplant recipients to die, but race and insurance were not independently predictive of mortality. Abstract
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Disease SiteGastrointestinal DiseaseTrimodality therapy without a platinum compound for localized carcinoma of the esophagus and gastroesophageal junction (p NA) For 55 patients with potentially resectable carcinoma of the esophagus, a novel nonplatinum 3-drug combination was used with radiation to assess toxicities and the pathologic complete response rate. These data suggested that a fluoropyrimidine with or without another cytotoxic (from any class of cytotoxics) can form a baseline regimen to which biologics can be added. Abstract
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Hepatobiliary DiseaseProgress for resectable cancer? : A population-based assessment of US practices (p NA) Despite reports of improved outcomes after resection for pancreatic cancer, many patients do not receive all elements ofguideline-directed care. Adherence is improving, but the survival benefit is gradual. Abstract
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Lung DiseaseInhibition of tumor growth and angiogenesis by a lysophosphatidic acid antagonist in an engineered three-dimensional lung cancer xenograft model (p NA) First, we optimize a three-dimensional encapsulation system for A549 cells that permits complete experimental control over the composition of the extracellular matrix used for encapsulation. Second, we demonstrate that a lysophosphatidic acid (LPA) receptor antagonist/autotaxin inhibitor dramatically reduces tumor volume and tumor vascularity, thus validating the LPA signaling pathway as a clinical target for the treatment of lung cancer. Abstract
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Hepatobiliary DiseaseIn-hospital mortality from liver resection for hepatocellular carcinoma : A simple risk score (p NA) There is a wide spectrum of disease burden in hepatocellular carcinoma accompanied by several options for surgical management, but the associated mortality of such procedures has not been well defined. In this study, the authors established that an integer-based risk score can be used to predict in-hospital mortality after surgery for hepatocellular carcinoma, and it may be useful for preoperative risk stratification and patient counseling. Abstract
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MelanomaTumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma (p NA) The current results indicated that programmed cell death-1 ligand 1 expression is correlated with tumor proliferation and patient survival. These data indicated the immunosuppressive aspect of melanoma. Abstract
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DisciplineOutcomes ResearchThe impact of breast reconstruction on the delivery of chemotherapy (p NA) Immediate postmastectomy breast reconstruction does not appear to lead to the omission of chemotherapy, but it is associated with a modest, but statistically significant, delay in initiating treatment. For most, it is unlikely that this delay has any clinical significance. Abstract
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Disease SiteGenitourinary DiseaseThe use of anticoagulants improves biochemical control of localized prostate cancer treated with radiotherapy (p NA) A substantial body of preclinical evidence describes the antineoplastic effect of anticoagulation agents, although the limited data from clinical studies have been mixed. In the current study, patients with prostate cancer who received radiotherapy with curative intent, the use of anticoagulants, including aspirin, warfarin, and clopidogrel, was associated with an improvement in biochemical control, especially for those with high-risk disease. Abstract
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DisciplineQuality of LifeEvaluating the ability to detect change of health-related quality of life in children with Hodgkin disease (p NA) We evaluated 4 different health-related quality of life measures prospectively to determine their ability to detect change over time: the Health Utilities Index Mark 2 and Mark 3, the Pediatric Quality of Life Inventory (PedsQL) 4.0 Generic Core and Cancer Module, the EuroQol EQ-5D visual analogue scale (EuroQol), and the Lansky Play-Performance Scale. All of the measures were able to detect change in a diverse group of children with Hodgkin disease, with the PedsQL and the EuroQol appearing to be the most sensitive to change. Abstract
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ErratumErratum (p NA) Abstract | Full Text:
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Original ArticlesDisease SiteGastrointestinal DiseaseEffectiveness of a patient- and practice-level colorectal cancer screening intervention in health plan members : Design and baseline findings of the CHOICE trial (p NA) The unique CHOICE (Communicating Health Options through Information and Cancer Education) trial design allows the assessment of colorectal cancer test completion via claims data for trial participants as well as nonrespondents. The results demonstrate the effect of 2 combined evidence-based interventions implemented in community settings among health plan members. Abstract
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Genitourinary DiseasePhase 1/2 study of preoperative docetaxel and mitoxantrone for high-risk prostate cancer (p NA) Preoperative chemotherapy with docetaxel and mitoxantrone in patients with clinically localized high-risk prostate cancer is feasible, with approximately half of the patients remaining free of disease recurrence at 5 years. Pretreatment serum prostate-specific antigen, lymph node involvement, and postchemotherapy tissue vascular endothelial growth factor expression were independent predictors of early recurrence. Abstract
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Neuro-OncologyPhase 2 trial of talampanel, a glutamate receptor inhibitor, for adults with recurrent malignant gliomas (p NA) Glioma cells secrete glutamate and also express AMPA glutamate receptors, which contribute to proliferation, migration, and neurotoxicity of malignant gliomas. A phase 2 trial of talampanel, an AMPA receptor inhibitor, was conducted. Thirty patients with recurrent malignant glioma were enrolled, and although talampanel was well-tolerated, it demonstrated no significant tumor activity as a single agent in this population. Abstract
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Review ArticlesKilling tumor cells through their surface Antibodies against Abstract
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Original ArticlesDisease SiteMelanomaSingle-institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting : Lymphocyte count after 2 doses correlates with survival (p NA) This description of 51 patients with advanced, treatment-refractory melanoma who were enrolled in a compassionate use trial of ipilimumab at Memorial Sloan-Kettering Cancer Center confirms that ipilimumab is active in this disease setting. In addition, the results suggest that the absolute lymphocyte count after 2 ipilimumab treatments (at Week 7) highly correlates with the rate of clinical benefit at Week 24 and overall survival. Abstract
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EditorialTumor progression by immune evasion in melanoma : Role of the programmed cell death-1/programmed cell death-1 ligand 1 interaction (p NA) In this editorial, the author reviews evidence supporting the role of the programmed cell death-1/programmed cell death-1 ligand 1 (PD-L1) interaction in the progression of melanoma and the role of PD-L1 as a potential prognostic factor for melanoma. Abstract
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Original ArticlesDisciplineTranslational ResearchDifferential methylation of cell-free circulating DNA among patients with pancreatic cancer versus chronic pancreatitis (p NA) By using methylation analysis of cell-free plasma DNA from blood, the authors developed a composite biomarker for distinguishing between pancreatic cancer and chronic pancreatitis that may be useful for differential detection of these diseases in a gastrointestinal clinic. To the authors' knowledge, this is the first report demonstrating that neoplastic and inflammatory diseases of the same organ can be detected differentially by a simple blood analysis. Abstract
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Disease SiteGastrointestinal DiseaseAbility of integrated positron emission and computed tomography to detect significant colonic pathology : The experience of a tertiary cancer center (p NA) A negative positron emission tomography and computed axial tomography does not rule out colon cancer, colonic lymphoma, advanced adenomas, or inflammatory conditions in the colon. Standardized uptake value readings had no relation to lesion size and were not useful in distinguishing true-positive exams from false-positive exams. Abstract
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DisciplineQuality of LifeNurses provide valuable proxy assessment of the health-related quality of life of children with Hodgkin disease (p NA) We prospectively compared the proxy reporting of health-related quality of life (HRQL) by parents and nurses of children with Hodgkin disease to see how well they correlated with the children's report. There was substantial agreement among the parent's, nurse's, and children's reported HRQL scores; moreover, nurses contribute valuable additional information as proxy respondents. Abstract
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Disease SiteBreast DiseaseImmunohistochemical surrogate markers of breast cancer molecular classes predicts response to neoadjuvant chemotherapy : A single institutional experience with 359 cases (p NA) Immunohistochemical criteria for corresponding molecular classes of breast cancer predict response to neoadjuvant chemotherapy. These criteria can be reliably applied in routine practice for prognostic/predictive information. Abstract
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Original ArticleDisease SiteGenitourinary DiseaseThe effect of changes in Medicare reimbursement on the practice of office and hospital-based endoscopic surgery for bladder cancer (p NA) After an increase in physician reimbursement, the use of office-based endoscopic bladder surgery doubled. Because this trend was not explained by office treatment of bladder cancer alone, it suggests that there was a reduced threshold for performing office-based endoscopic bladder procedures in the period after changes in Medicare reimbursement. Abstract
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Original ArticlesDisciplinePsychosocial OncologyThe role of socioeconomic status in adjustment after ductal carcinoma in situ (p NA) Women with medium or low socioeconomic status were vulnerable to escalating anxiety and depression after ductal carcinoma in situ diagnosis. We recommend that women with low financial status be provided with psychosocial interventions that are designed to accommodate their unique needs. Abstract
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CorrespondenceReply to Promoter methylation of glutathione S-transferase Abstract
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Promoter methylation of glutathione S-transferase Abstract
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Original ArticlesDisease SiteHead and Neck DiseasePharyngoesophageal reconstruction with the anterolateral thigh flap after total laryngopharyngectomy (p NA) The authors' experience with pharyngoesophageal reconstruction using the anterolateral thigh flap achieved superior clinical and functional outcomes and significantly less donor site morbidity than traditional methods. Abstract
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Review ArticlesDisease SiteHematologic MalignanciesOptimizing therapy for patients with chronic myelogenous leukemia in chronic phase (p NA) Although the treatment of chronic myelogenous leukemia (CML) has improved significantly since the advent of imatinib and, more recently, the second-generation tyrosine kinase inhibitors dasatinib and nilotinib, there remains an urgent need to optimize therapy for individual patients. The objectives of this review article are to offer physicians a comprehensive review of the current literature and provide data supporting various treatment options for patients with CML throughout the course of imatinib therapy and beyond. Abstract
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Original ArticlesDisciplineQuality of LifeNative American breast cancer survivors' physical conditions and quality of life (p NA) For the first time, survivorship issues are reported specifically for Native American breast cancer patients (n = 266). Half of the patients had difficulties accessing treatment services, and unmanaged cancer pain was among the more prevalent problems. Abstract
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Disease SiteGastrointestinal DiseasePredictors of a true complete response among disappearing liver metastases from colorectal cancer after chemotherapy (p NA) Approximately 66% of patients who have disappearing liver metastases have a true complete response according to assessment by resection or radiologic follow-up. Predictive factors, such as the use of hepatic arterial infusion chemotherapy, inability to observe the metastasis on magnetic resonance imaging, and normalization of the serum carcinoembryonic antigen level, help to stratify patients who are likely to harbor residual disease. Abstract
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DisciplineClinical TrialsA phase 2 pilot trial of low-dose, continuous infusion, or Patients with metastatic melanoma were treated with metronomic doses of paclitaxel and celecoxib. The results demonstrated that this combination can lead to disease stabilization in a proportion of patients. Abstract
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Radiation OncologyPapillary microcarcinoma of the thyroid among atomic bomb survivors : Tumor characteristics and radiation risk (p NA) Exposure to low-to-moderate doses of ionizing radiation appears to be associated with an elevated risk of thyroid papillary microcarcinoma, even when exposure occurs during adulthood. See related editorial pages 000-000. Abstract
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Disease SiteSarcomaPrediction of pathologic fracture risk of the femur after combined modality treatment of soft tissue sarcoma of the thigh (p NA) Radiation-related fractures of the femur occurring after surgery and radiotherapy for soft tissue sarcoma are uncommon but difficult to manage, and their nonunion rate is extremely high. The proposed model, presented as a nomogram, suggests that it is possible to predict a patient's risk of fracture with a high degree of sensitivity and specificity, which would allow for the identification of high-risk patients before fracture occurs. Abstract
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Gastrointestinal DiseaseWeekly docetaxel, cisplatin, and 5-fluorouracil as initial therapy for patients with advanced gastric and esophageal cancer (p NA) In patients with advanced gastroesophageal cancer who were not candidates for therapy with every-3-week docetaxel, cisplatin, and 5-flurouracil (DCF), a weekly formulation of DCF demonstrated modest activity with minimal hematologic toxicity. Further schedule optimization for these 3 active agents is recommended. Abstract
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Review ArticlesPathogenesis of osteoblastic bone metastases from prostate cancer (p NA) Prostate cancer cells metastasize to bone, undergoing an epithelial-mesenchymal transition to disseminate and acquire a bone-like phenotype to grow in bone tissue. Metastasization is the result of dynamic crosstalk between metastatic cancer cells, and cellular components of the bone marrow microenvironment and bone matrix (osteoblasts and osteoclasts). Abstract
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CommentaryGuide for investigators conducting international cancer research involving developing nations (p NA) International studies of cancer will increasingly involve collaboration with underdeveloped countries. These research partnerships will also strengthen communication and understanding between diverse populations. Abstract
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Original ArticlesDisciplineClinical TrialsA randomized phase 2 study of etaracizumab, a monoclonal antibody against integrin Preclinical studies suggested that antibodies against the Abstract
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PathologyProposed adjustments to pathologic staging of epithelial malignant pleural mesothelioma based on analysis of 354 cases (p NA) Existing staging systems for diffuse malignant pleural mesothelioma do not provide accurate survival stratification for patients undergoing primary surgery. Proposed adjustments to pathologic TNM staging criteria improve outcome stratification of patients with epithelial tumor histology who receive definitive surgical therapy by extrapleural pneumonectomy. Abstract
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Disease SiteBreast DiseaseStage IV breast cancer in the era of targeted therapy : Does surgery of the primary tumor matter? (p NA) Surgical resection of the primary tumor was found to be associated with a trend toward improved survival in patients with stage IV breast cancer who were treated entirely in the modern era. This trend was observed most strongly in the subset of patients with estrogen receptor/progesterone receptor positive and/or HER-2/neu-amplified disease and suggests that the impact of local control is most evident in the presence of effective targeted therapy. Abstract
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Gastrointestinal DiseaseAZD6244 (ARRY-142886) enhances the antitumor activity of rapamycin in mouse models of human hepatocellular carcinoma (p NA) We used the mouse models of human hepatocellular carcinoma (HCC), which recapitulate many features of human HCC, to test the antitumor and antiangiogenic effects of AZD6244/RAPA combination. We now report that combinatorial inhibition of the mTOR and MEK/ERK signaling pathways was highly effective for inhibition of HCC growth and angiogenesis in vivo. Our findings provide the rationale for combining MEK and mTORC1 inhibitors in the treatment of HCC. Abstract
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Review ArticleAdult acute lymphoblastic leukemia : Concepts and strategies (p NA) Acute lymphoblastic leukemia (ALL) has been a success story in pediatric oncology. Although results in adults lag behind those in children, an expansion of new drugs, more reliable immunologic and molecular techniques for the assessment of minimal residual disease, and efforts at more precise risk stratification are generating new expectations for adult ALL therapy. Abstract
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Original ArticlesDisciplineOutcomes ResearchRace, ethnicity, and socioeconomic status influence the survival of patients with hepatocellular carcinoma in the United States (p NA) Significant racial and ethnic disparities in the outcome of patients with hepatocellular carcinoma persist despite the receipt of comparable treatment. Controlling for other clinical factors, black race was associated with the worst survival after surgical treatment and the worst graft survival and overall survival after liver transplantation, whereas Hispanics had the best transplantation outcomes. Abstract
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Disease SiteGynecologic OncologyPelvic lymph node F-18 fluorodeoxyglucose uptake as a prognostic biomarker in newly diagnosed patients with locally advanced cervical cancer (p NA) In the current study, the authors evaluated the prognostic significance of the maximum standardized uptake value (SUV) of pelvic lymph nodes in patients with cervical cancer. The SUV in pelvic lymph nodes was found to be a prognostic biomarker, predicting treatment response, risk of pelvic disease recurrence, and disease-specific survival. Abstract
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DisciplineMedical OncologyPhase 1 pharmacokinetic and drug-interaction study of dasatinib in patients with advanced solid tumors (p NA) The authors conducted a phase 1 trial of dasatinib in patients with advanced solid tumors and determined a maximum recommended dose of 180 mg once daily based on the incidence of pleural effusion. Coadministration of dasatinib with the cytochrome P450 3A4 inhibitor ketoconazole led to a marked increase in dasatinib exposure, which was correlated with an increase in corrected QT values but not with cardiac toxicity. Abstract
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Disease SiteGynecologic OncologyMucinous but not clear cell histology is associated with inferior survival in patients with advanced stage ovarian carcinoma treated with platinum-paclitaxel chemotherapy (p NA) Mucinous but not clear cell histology is associated with significantly worse prognosis in advanced ovarian cancer treated with combination platinum/paclitaxel. Different therapeutic strategies should be studied in this entity. Abstract
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Neuro-Oncology5-Aminolevulinic acid is a promising marker for detection of anaplastic foci in diffusely infiltrating gliomas with nonsignificant contrast enhancement (p NA) Data indicate that 5-aminolevulinic acid (5-ALA) is a promising marker for intraoperative visualization of anaplastic foci in diffusely infiltrating gliomas with nonsignificant contrast enhancement. The use of 5-ALA may become a novel standard for intraoperative tissue sampling in these tumors, and may therefore optimize allocation of patients to adjuvant treatments. Abstract
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MelanomaShould all patients with melanoma between 1 and 2 mm Breslow thickness undergo sentinel lymph node biopsy? (p NA) The authors observed that there is significant diversity of biologic behavior of melanoma between 1 mm and 2 mm in thickness. Sentinel lymph node biopsy is recommended for all such patients to identify those with lymph node metastasis who are at the greatest risk of recurrence and mortality. Abstract
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EditiorialsRadiation versus resection for Merkel cell carcinoma (p NA) A report by Fang et al on lymph node disease in patients with Merkel cell carcinoma suggests that radiation monotherapy is an effective modality for regional disease control compared with lymphadenectomy. However, the selection bias inherent in retrospective studies must be considered before changing practice patterns. Abstract
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EditorialsThe heterogeneity of epithelial ovarian cancer : Getting it right (p NA) Epithelial ovarian cancer is heterogeneous and comprises 4 major rare subtypes - mucinous, clear cell, low-grade serous, and endometrioid - all distinct from the more common high-grade serous carcinoma. Women with uncommon histotypes should be triaged to separate clinical trials. Abstract
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Original ArticlesDisease SiteHematologic MalignanciesPhase 2 study of intrathecal, long-acting liposomal cytarabine in the prophylaxis of lymphomatous meningitis in human immunodeficiency virus-related non-Hodgkin lymphoma (p NA) Patients with aggressive non-Hodgkin lymphoma and human immunodeficiency virus infection benefit from the use of liposomal cytarabine (DepoCyte) as prophylaxis against meningeal disease recurrence or progression. Abstract
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Lung DiseaseFive-year lung cancer survival : Which advanced stage nonsmall cell lung cancer patients attain long-term survival? (p NA) Despite aggressive multimodality therapy, 5-year survival in patients with advanced stage nonsmall cell lung cancer (NSCLC) was very poor and for the most part limited to small and specific pathologic subsets including resectable N2 disease, multiple primary tumors, T3N0, and single site distant metastasis. Patients with advanced stage NSCLC who did not fit into 1 of these subsets had a small chance of long-term survival. Abstract
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DisciplineOutcomes ResearchProstate cancer treatment for economically disadvantaged men : A comparison of county hospitals and private providers (p NA) In this economically disadvantaged cohort, prostate cancer care differed significantly between county hospitals and private providers. This study - the first to compare prostate cancer treatments between different types of healthcare facilities - reveals substantial variations in care that merit further investigation. Abstract
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CorrespondenceEarly changes in tumor size in patients treated for advanced stage nonsmall cell lung cancer do not correlate with survival (p NA) Abstract
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EditorialsRefining the criteria for sentinel lymph node biopsy in patients with thinner melanoma : A roadmap for the future (p NA) Numerous studies validate the standard practice of sentinel lymph node biopsy for patients with melanoma, and recent results from the Sunbelt Melanoma Trial highlight its important prognostic role in patients with thinner (1.0 mm-2.0 mm) melanomas. Future studies including large, unselected groups of patients with thin melanoma undergoing thorough pathologic microstaging of both the primary and the sentinel node are necessary to address remaining questions and aid in refining selection criteria for this procedure. Abstract
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Original ArticlesDisciplineClinical TrialsA phase 2 study of a fixed combination of uracil and ftorafur (UFT) and leucovorin given orally in a 3-times-daily regimen to treat patients with recurrent metastatic breast cancer (p NA) The combination of uracil and ftorafur (UFT) and leucovorin administered orally in a 3-times-daily regimen is reported to have modest activity in patients with metastatic breast cancer who had been previously treated with anthracyclines and/or taxanes. Grade 3 toxicities were manageable. Abstract
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EditorialsMedicare reimbursement changes for bladder biopsies : A cautionary tale of unintended consequences (p NA) Medicare reimbursement policies may have unintended consequences. These are not always negative. Abstract
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Original ArticlesDisease SiteGynecologic OncologyTen-year follow-up of a phase 2 study of dose-intense paclitaxel with cisplatin and cyclophosphamide as initial therapy for poor-prognosis, advanced-stage epithelial ovarian cancer (p NA) Dose-intense paclitaxel, cyclophosphamide, and cisplatin with flexible filgrastim dosing yielded a high surgical response rate and encouraging overall survival in patients with advanced epithelial ovarian cancer. These data and those recently reported by the Japanese Oncology Group suggest that further study of dose-dense or dose-intense regimens may be warranted. Abstract
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Breast DiseaseAxillary sentinel lymph node biopsy after neoadjuvant chemotherapy for carcinoma of the breast (p NA) The timing and accuracy of axillary sentinel lymph node biopsy in patients who receive neoadjuvant chemotherapy for breast cancer is controversial. In the authors' experience with sentinel lymph node biopsy after neoadjuvant chemotherapy in 79 patients from 1997 through 2008, the successful identification of sentinel lymph nodes was documented in 98.7% of patients with an accuracy >92%. Abstract
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Lung DiseaseElevated levels of the acute-phase serum amyloid are associated with heightened lung cancer risk (p NA) The findings from this study clearly indicated that the elevation of acute-phase serum amyloid protein A was associated with a substantial risk of developing lung cancer in a heavy smoking population. The results were based on the assessment of low-dose, spiral computed tomography scans from a control group and from a large number of patients who had screen-detected, early stage lung cancer. Abstract
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Head and Neck DiseaseGenetic alterations between primary head and neck squamous cell carcinoma and recurrence after radiotherapy : Recurrence, genetically related cancer, or second primary? (p NA) The molecular profiles of primary tumors and recurrences were compared; where a recurrence after radiotherapy is found, the timing of reappearance together with the genetic comparison could help to tailor more appropriate salvage treatment. The authors found that tumors with partially discordant mutations display more aggressive behavior. Abstract
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DisciplinePediatric OncologyLong-term outcomes of childhood cancer survivors in Sweden: A population-based study of education, employment, and income (p NA) Swedish non-central nervous system cancer survivors had similar education, employment, and income as the general population, indicating the efficacy of surveillance, societal remedial measures, or both. However, brain tumor survivors presented with poorer socioeconomic outcomes, even after exclusion of those with indicated disability. Abstract
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Clinical TrialsPhase 2 trial of primary systemic therapy with doxorubicin and docetaxel followed by surgery, radiotherapy, and adjuvant chemotherapy with cyclophosphamide, methotrexate, and 5-fluorouracil based on clinical and pathologic response in patients with stage IIB to III breast cancer : Long-term results from The University of Texas M. D. Anderson Cancer Center Study ID97-099 (p NA) The authors reported a phase 2 trial of neoadjuvant chemotherapy in patients with inoperable and locally advanced breast cancer who were treated with anthracyclines and taxanes followed by local treatment based on clinical and pathologic response. The authors published mature data with a median follow-up of 8 years. Abstract
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Review ArticlesLocoregional treatment of primary breast cancer : Consensus recommendations from an International Expert Panel (p NA) Guidelines for the locoregional treatment of primary breast cancer were last published by the US National Institutes of Health in 1991. New surgical and radiotherapeutic techniques and new clinical evidence since then have created a need for revised guidelines for the locoregional treatment of primary breast cancer. Abstract
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Original ArticlesDisease SiteGenitourinary DiseaseSafety and efficacy results of the advanced renal cell carcinoma sorafenib expanded access program in North America (p NA) The authors report on the results of sorafenib administration in an expanded access program to patients with advanced renal cell carcinoma. Abstract
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Lung DiseaseSurvival outcomes with the use of surgery in limited-stage small cell lung cancer : Should its role be re-evaluated? (p NA) The use of surgery, particularly lobectomy, in selected patients with limited-stage small cell lung cancer was associated with improved survival outcomes. The authors of this report concluded that future prospective studies should consider the role of surgery as part of the multimodality management of these patients. Abstract
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DisciplineMedical OncologyEpidermal growth factor receptor expression in breast cancer association with biologic phenotype and clinical outcomes (p NA) Although epidermal growth factor receptor (EGFR) has a potent impact on breast cancer preclinical models, clinical studies on this biomarker yielded mixed results. This article provides EGFR expression data and its associated clinical and biologic phenotypes on a large set of breast tumors, along with long follow-up and outcome data. Abstract
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Review ArticlesImplications of key trials in advanced nonsmall cell lung cancer (p NA) Among the numerous targeted agents investigated in first-line advanced nonsmall cell lung cancer (NSCLC), only bevacizumab and cetuximab have demonstrated overall survival improvements. The clinical development of these agents indicate that approaches based in randomized phase 2 trials before transitioning to phase 3 may have better chances of success. In addition, sound clinical development for any agent in NSCLC in the near future will almost certainly depend on reliable patient selection strategies. Abstract
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Original ArticlesDisciplineMedical OncologyTumor suppressor XIAP-Associated factor 1 (XAF1) cooperates with tumor necrosis factor-related apoptosis-inducing ligand to suppress colon cancer growth and trigger tumor regression (p NA) Combined treatment with adeno- XIAP-associated factor 1 (XAF1) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) strongly enhanced the induction of apoptosis in vivo, significantly inhibited tumor growth, markedly prolonged the survival time of animals bearing colon tumor xenografts, and completely eradicated established tumors. The results suggest that the combination of XAF1 and TRAIL may be a potent strategy for colon cancer treatment. Abstract
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Original ArticleDisciplineMedical OncologyPhase 2 study of irinotecan and paclitaxel in patients with recurrent or refractory small cell lung cancer (p NA) The combination of irinotecan and paclitaxel combination is reported to be tolerated well in patients with recurrent small cell lung cancer. The regimen is active in patients with both sensitive and refractory disease recurrence. Abstract
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Review ArticlesTreatment of small-cell lung cancer in elderly patients (p NA) Although standard approaches for the treatment of small-cell lung cancer seem feasible in carefully selected elderly patients, the majority of data are drawn from retrospective studies, which are likely to suffer from selection bias. Prospective clinical trials specifically of the elderly are mandatory to provide evidence-based recommendations for the treatment of this special population. Abstract
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Original ArticlesDisease SiteHepatobiliary DiseaseTherapeutic equivalence in survival for hepatic arterial chemoembolization and yttrium 90 microsphere treatments in unresectable hepatocellular carcinoma : A Two-Cohort Study (p NA) Consecutive cohorts of patients (n = 932) with unresectable hepatocellular carcinoma (HCC) underwent either repeated, cisplatin-based chemoembolization or transhepatic arterial chemoembolization (n = 691); or received a planned, single dose of intrahepatic arterial yttrium 90 microspheres (n = 99); or received no therapy (n = 142) and were followed until death. After patients were stratified into subgroups defined by liver function (bilirubin <1.5 mg/dL or >1.5 mg/dL), tumor extension (the presence or absence of portal vein thrombosis), or the presence or absence of elevated Abstract
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Genitourinary DiseaseIs delayed radical prostatectomy in men with low-risk screen-detected prostate cancer associated with a higher risk of unfavorable outcomes? (p NA) Men with low-risk screen-detected prostate cancer who received immediate surgery were compared with men receiving surgery after an initial period of expectant management. No significant differences in histopathological or biochemical outcomes were observed. Abstract
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Lung DiseaseFrequent central nervous system failure after clinical benefit with epidermal growth factor receptor tyrosine kinase inhibitors in Korean patients with nonsmall-cell lung cancer (p NA) The central nervous system (CNS) was frequently the initial failure site after a clinical benefit to epidermal growth factor tyrosine kinase inhibitors (EGFR-TKIs) in Korean nonsmall-cell lung cancer patients. A role of prophylactic cranial irradiation or close surveillance on the CNS during EGFR-TKI treatment is worthy of further study in these selected patients. Abstract
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EditorialThe persistent anchor of lymph node removal in patients with melanoma (p NA) Sentinel lymph node dissection is the most accurate method with which to identify regional metastases in clinically lymph node-negative patients with melanoma. Attempts to define which sentinel lymph node-positive patients will benefit from completion lymphadenectomy fall short and raise even more questions. Abstract
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Review ArticlesEarly (sentinel lymph node biopsy-guided) versus delayed lymphadenectomy in melanoma patients with lymph node metastases : Personal Experience and Literature Meta-Analysis (p NA) The authors compared the survival of patients with melanoma and lymph node metastases (n = 190) who underwent either early lymphadenectomy (after a positive sentinel lymph node biopsy) or delayed lymphadenectomy (for clinically evident disease) at their institution and also conducted a systematic review and meta-analysis of the literature on this issue. Although, in 2 series (including the authors' own), no significant difference in survival was observed, the pooling of summary data from all studies (n = 2633) that addressed this issue suggested that early lymphadenectomy is associated with a significantly better outcome. Abstract
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Original ArticlesDisease SiteHead and Neck DiseaseN1S3: A revised staging system for head and neck cutaneous squamous cell carcinoma with lymph node metastases : Results of 2 Australian Cancer Centers (p NA) A staging system for metastatic head and neck cutaneous squamous cell carcinoma that would be usable and applicable in all clinical settings and provide improved prognostic discrimination is long overdue. The proposed N1S3 system uses independent pathological variables to stage patients and has been externally validated. Abstract
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CorrespondenceReply to early changes in tumor size in patients treated for advanced stage nonsmall cell lung cancer do not correlate with survival (p NA) Abstract
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Original ArticlesDisease SiteNeuro-OncologyClinical characteristics and outcomes for a modern series of primary gliosarcoma patients (p NA) Primary gliosarcoma is a rare central nervous system malignancy with limited experience reported in the literature. The current modern series of 20 primary gliosarcoma patients reported herein supports the existence of 2 clinically distinct subtypes of primary gliosarcoma. Abstract
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Review ArticlesDisease SiteSarcomaAntiangiogenesis agents in the treatment of soft tissue sarcomas (p NA) Antiangiogenesis agents for soft tissue sarcomas are an attractive therapeutic option. The objective of this article was to review the angiogenesis surrogate markers and antiangiogeneis trials in soft tissue sarcoma. Abstract
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Cancer survivorship: Embracing the future North Bethesda, MD (p NA) Abstract | Full Text:
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2-microglobulin or major histocompatibility complex class I molecules (p NA)
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1 and multidrug resistance gene 1 in bronchioloalveolar carcinoma and its correlation with DNA methyltransferase 1 expression (p NA)
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paclitaxel and oral celecoxib in patients with metastatic melanoma (p NA)
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