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  Published on behalf of the American Cancer Society Journal Home | OnlineOpen | Society Information | News | Professional Opportunities Overview | Editorial Board | Author Guidelines | Access Policy | Subscribe | Advertise | Contact | Submit an Article Early View(Articles online in advance of print)Original ArticlesDisciplineEpidemiologyCancer incidence in the multicenter aids cohort study before and during the HAART era : 1984 to 2007 (p NA) Since the introduction of highly active antiretroviral therapy (HAART) in the mid-1990s, the incidence of Kaposi sarcoma and non-Hodgkin lymphoma in people infected with the human immunodeficiency virus (HIV) has dropped dramatically. A decade later, however, HIV infection remains significantly associated with an elevated risk of these cancers, Hodgkin lymphoma, and anal cancer. Abstract
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 Disparities ResearchQuality of cancer care among foreign-born and US-born patients with lung or colorectal cancer (p NA) Foreign-born patients with lung or colorectal cancer in the United States reported a lower quality of care and were less likely to receive some recommended cancer therapies than US-born patients. These differences were partly explained by English language proficiency. Abstract
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Clinical TrialsDysembryoplastic neuroepithelial tumors and cognitive outcome : Cure at a price? (p NA) Data were reviewed regarding dysembryoplastic neuroepithelial tumors. The recurrence and progression rates of dysembryoplastic neuroepithelial tumors and the high rate of abnormal neurocognitive test results noted in this study highlight the need for regular follow-up and appropriate academic counseling of children with these tumors. Abstract
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Disease SiteHematologic MalignanciesMaintenance therapy with low-dose azacitidine after allogeneic hematopoietic stem cell transplantation for recurrent acute myelogenous leukemia or myelodysplastic syndrome : A dose and schedule finding study (p NA) Azacitidine may decrease the disease recurrence rate after allogeneic transplants for advanced acute myelogenous leukemia or myelodysplastic syndrome. The authors determined that the maximum tolerated dose is 32 mg/m2 for 5 days, in monthly cycles. Abstract
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Hepatobiliary DiseaseMidterm outcomes in patients with intermediate-sized hepatocellular carcinoma : A randomized controlled trial for determining the efficacy of radiofrequency ablation combined with transcatheter arterial chemoembolization (p NA) The authors conducted a randomized controlled trial to evaluate the advantages of combining radiofrequency ablation (RFA) with transcatheter arterial chemoembolization (TACE) for treating patients with intermediate-sized (3.1-5.0 cm) hepatocellular carcinomas. The results showed that the local tumor progression rate in the TACE-RFA group was lower than that in the RFA group; however, there was no statistical difference between the overall survival rates and safety in the 2 groups. Abstract
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DisciplinePediatric OncologyOsteosarcoma in very young children : Experience of the Cooperative Osteosarcoma Study Group (p NA) The incidence of high-grade osteosarcoma varies considerably with age, and preschool children are very rarely affected, with a total of only 27 well described cases in the literature. We present detailed information on the Cooperative Osteosarcoma Study Group (COSS) experience on a total of 28 children aged younger than 5 years at diagnosis. Abstract
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Disease SiteHematologic MalignanciesPhase 1 trial of bortezomib plus R-CHOP in previously untreated patients with aggressive non-Hodgkin lymphoma (p NA) In vitro studies have suggested that bortezomib can enhance the efficacy of chemotherapy. This phase 1 study demonstrated that bortezomib at a dose of 1.3 mg/m2 twice per cycle can be added to the regimen of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) with acceptable toxicity. Abstract
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DisciplineOutcomes ResearchContinued chemotherapy after complete response to primary therapy among women with advanced ovarian cancer : A meta-analysis (p NA) A meta-analysis of consolidation and maintenance therapy for ovarian cancer showed a significant advantage for both progression-free and overall survival, particularly among patients with advanced stage disease who reached complete clinical or pathologic response after primary therapy. Abstract
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Disease SiteNeuro-OncologyA phase 2 trial of single-agent bevacizumab given in an every-3-week schedule for patients with recurrent high-grade gliomas (p NA) Single-agent bevacizumab given every 3 weeks was active and was comparable to a 2-week schedule. The current results indicated that the ratio of vascular endothelial growth factor (VEGF) to VEGF receptor may be predictive of activity. Abstract
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Review ArticlesLymphedema beyond breast cancer : A systematic review and meta-analysis of cancer-related secondary lymphedema (p NA) This systematic review and meta-analysis of the oncology-related literature reports incidence estimates for secondary lymphedema and risk factors among various malignancies apart from breast cancer. Abstract
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Original ArticlesDisease SiteGynecologic OncologyThe molecular pathogenesis of hereditary ovarian carcinoma : Alterations in the tubal epithelium of women with BRCA1 and BRCA2 mutations (p NA) Molecular changes in fallopian tube epithelium of women with BRCA1 and BRCA2 mutations offer new insight into the pathogenesis of hereditary ovarian carcinoma. Abstract
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Hematologic MalignanciesDoes combination of lipid formulation of amphotericin B and echinocandins improve outcome of invasive aspergillosis in hematological malignancy patients? (p NA) The authors evaluated salvage therapy with lipid formulations of amphotericin B, echinocandin, or a combination of both for refractory aspergillosis in a patient population with hematological malignancy. Our data suggest that combination therapy offered no additional benefit compared with either drug administered as a single agent in respect to clinical response and mortality. Abstract
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EditorialsExamining the association between delay in diagnosis and decreased survival in bladder cancer (p NA) Delays in diagnosis and definitive treatment are associated with poorer survival in observational studies of patients with bladder cancer. Quality of care may be as important as tumor biology in explaining this association. Abstract
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Original ArticlesDisease SiteBreast DiseaseUtility of oncotype DX risk estimates in clinically intermediate risk hormone receptor-positive, HER2-normal, grade II, lymph node-negative breast cancers (p NA) Oncotype DX yielded potentially informative risk assignments in patients considered to be at indeterminate risk by routine clinical variables. However, 40% of the time, the tests results remained intermediate risk with widely used in recurrence score thresholds. This proportion increased to 66% when revised thresholds implemented by the National Cancer Institute's Trial Assigning IndividuaLized Options for Treatment (Rx), or TAILORx, were used. Abstract
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Review ArticlesThe role of kinesin family proteins in tumorigenesis and progression : Potential biomarkers and molecular targets for cancer therapy (p NA) The authors reviewed in detail the structure and function of kinesin family proteins, the correlation of kinesin expression with tumorigenesis, and the development of biomarkers for cancer diagnosis, prognosis, and therapy. Abstract
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Original ArticlesDisease SiteBreast DiseaseQuantitative HER2 protein levels predict outcome in fluorescence in situ hybridization-positive patients with metastatic breast cancer treated with trastuzumab (p NA) By using a novel assay (HERmark) to quantify total human epidermal growth factor receptor 2 (HER2) and HER2 homodimeric protein levels in primary breast tumor tissue sections, the authors examined outcomes in 102 trastuzumab-treated metastatic breast cancer patients previously assessed as immunohistochemistry 3+ or fluorescence in situ hybridization (FISH) positive, and then retested by central FISH. A subset of patients with HER2 gene amplification by FISH expressed low levels of HER2 protein and had reduced response to trastuzumab-containing therapy, similar to FISH-negative patients. Abstract
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DisciplineEpidemiologyRelationship between current level of immunodeficiency and non-acquired immunodeficiency syndrome-defining malignancies (p NA) Low CD4 count is associated with increased risk of non-acquired immunodeficiency syndrome (AIDS)-defining malignancies. Starting human immunodeficiency virus-infected patients on combination antiretroviral therapy before immunodeficiency develops is important to decrease the risk of developing many common non-AIDS-related malignancies, especially those that are virus-related. Abstract
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Review ArticlesPerspective on updated treatment guidelines for patients with gastrointestinal stromal tumors (p NA) In this review, the authors summarized the latest recommendations provided by the 2009 European Society of Medical Oncology and National Comprehensive Cancer Network (soft tissue sarcoma) guidelines on the management of gastrointestinal stromal tumors. In addition, the 2006 Canadian guidelines and other relevant guidelines are mentioned intermittently mentioned throughout the article. The objectives of this review were to bring to light recommendations for which the guidelines reach a consensus and to identify gaps and potential nuances in the differences among them. Abstract
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Original ArticlesDisciplineClinical TrialsIntensively timed combination chemotherapy for the induction of adult patients with acute myeloid leukemia : Long-term follow-up of a phase 2 study (p NA) Timed sequential chemotherapy as was applied in a successful pediatric acute myeloid leukemia (AML) trial was given to adults with AML. Toxicity was significant, but was counterbalanced by improved disease-free survival. Abstract
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Disease SiteGynecologic OncologyCombination of gemcitabine and cisplatin is highly active in women with endometrial carcinoma : Results of a prospective phase 2 trial (p NA) The combination chemotherapy regimen of gemcitabine and cisplatin appears to be active in women with recurrent or advanced endometrial cancer. This therapy results in a 50% objective response rate and manageable toxicity. Abstract
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Gastrointestinal DiseaseMicrosatellite instability among individuals of Hispanic origin with colorectal cancer (p NA) Among individuals with colorectal cancer (CRC), microsatellite instability (MSI) status may have implications for prognosis, therapy, and counseling, but to the authors' knowledge, MSI prevalence has not been clearly defined among individuals of Hispanic origin with CRC. In the current study, the authors report that the prevalence of MSI CRC among Hispanic individuals may be similar to that of other races and ethnicities, but clinicopathological characteristics, including age at diagnosis and type of abnormal mismatch repair protein expression, suggest that sporadic MSI CRC may be less common in individuals of Hispanic origin. Abstract
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Obesity adversely affects survival in pancreatic cancer patients (p NA) Obesity as measured by increased body mass index (BMI) is associated with decreased survival in those diagnosed with pancreatic cancer, after adjusting for known confounders. BMI should be considered as a covariate in prospective studies of pancreatic cancer. Abstract
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Lung DiseaseLimited resection followed by intraoperative seed implantation is comparable to stereotactic body radiotherapy for solitary lung cancer (p NA) The current results demonstrated comparable efficacy in outcome and toxicity between surgical resection with radioactive seed implantation and stereotactic body radiotherapy for the treatment of single malignant lung nodules in patients who were not candidates for lobectomy/pneumonectomy. Abstract
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Gynecologic OncologyChange in fibroblast growth factor 2 expression as an early phase radiotherapy-responsive marker in sequential biopsy samples from patients with cervical cancer during fractionated radiotherapy (p NA) The results from this study indicated that changes in immunohistologic fibroblast growth factor 2 expression in cervical cancer cells obtained from biopsies before and during radiotherapy can be used as a marker to monitor the effectiveness of radiotherapy. Abstract
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DisciplineSymptom Control and Palliative CareMethylphenidate for fatigue in ambulatory men with prostate cancer (p NA) This is the first randomized placebo-controlled trial of a psychostimulant for fatigue in a prostate cancer population. Data from this study, which should be considered preliminary, suggest that methylphenidate is effective in treating fatigue in men with prostate cancer; however, oncologists need to monitor these men regularly for possible pulse and blood pressure elevations. Abstract
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Translational ResearchThe prognostic value of c-Kit, K-ras codon 12, and p53 codon 72 mutations in Egyptian patients with stage II colorectal cancer (p NA) In this study, c-Kit overexpression, mutations in codons 12 and 13 of the Kirsten rat sarcoma viral oncogene homolog (K-ras) gene, and mutations in codon 72 of the tumor protein 53 (p53) gene proved to be independent prognostic factors in patients with stage II colorectal cancer (CRC) and should be added to standard prognostic factors for better evaluation of patients. In addition, the current results indicated that Egyptian patients with stage II CRC have a unique mutational pattern of p53 that differs from the pattern reported among patients in the United States and Western countries. Abstract
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Disease SiteHematologic MalignanciesPretransplantation [18-F]fluorodeoxyglucose positron emission tomography scan predicts outcome in patients with recurrent Hodgkin lymphoma or aggressive non-Hodgkin lymphoma undergoing reduced-intensity conditioning followed by allogeneic stem cell transplantation (p NA) Disease assessment on an [18-F]fluorodeoxyglucose positron emission tomography (PET) scan before allogeneic stem cell transplantation was capable of predicting long-term survival in patients with recurrent and chemosensitive Hodgkin lymphoma or aggressive non-Hodgkin lymphoma, because the patients who had negative PET scans were at lower risk of recurrence and had better progression-free and overall survival than the patients who had positive PET scans. The predictive value of PET was independent of graft-versus-host disease and the graft-versus-lymphoma effect. Abstract
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Current patient management of chronic myeloid leukemia in Latin America : A study by the Latin American Leukemia Net (LALNET) (p NA) A survey of 435 physicians in 16 Latin American countries revealed that in general most follow current recommendations for the use of imatinib to treat patients with chronic myeloid leukemia (CML). However, significant variability is evident regarding the management of CML patients, determined in great part by availability of resources. Abstract
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CommentariesBypassing phase 1 trials in the cancer drug development paradigm: Generally unwise and potentially dangerous (p NA) Although the primary purpose of phase 1 trials is the determination of safety, these early clinical investigative efforts are also associated with several important secondary endpoints that are essential to future drug development. Unfortunately, there has been a recent trend in which some oncology investigators have suggested bypassing formal phase 1 testing of presumably theoretically attractive new/novel antineoplastic drug combinations. This commentary challenges the need for, and wisdom of, this approach and highlights the potential danger to research subjects participating in later stage trials that are not supported by rigorous phase 1 data. Abstract
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CommunicationsTNM seventh edition: What's new, what's changed : Communication from the International Union Against Cancer and the American Joint Committee on Cancer (p NA) The seventh edition of the TNM Classification of Malignant Tumors contains several new and modified component classifications. The purpose of this communication was to briefly summarize these changes. Abstract
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Original ArticlesDisciplineMedical OncologyUse of white blood cell growth factors and risk of acute myeloid leukemia or myelodysplastic syndrome among elderly patients with non-Hodgkin lymphoma (p NA) The administration of colony-stimulating factor among elderly patients with non-Hodgkin lymphoma who were receiving chemotherapy was associated with an increased risk of myelodysplastic syndromes or acute myeloid leukemia, although the absolute risk was low. Abstract
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Disease SiteGenitourinary DiseaseVascular endothelial growth factor-targeted therapy for the treatment of adult metastatic Xp11.2 translocation renal cell carcinoma (p NA) Adult Abstract
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Gastrointestinal DiseaseExpression of p16INK4A but not hypoxia markers or poly adenosine diphosphate-ribose polymerase is associated with improved survival in patients with pancreatic adenocarcinoma (p NA) Immunohistochemical analysis was performed on tumors of 73 patients with resected pancreatic adenocarcinoma. Patients with nuclear expression of the tumor suppressor gene product p16INK4A had improved survival compared with those with no expression, which was confirmed on multivariate analysis. Abstract
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Notch1 regulates the growth of human colon cancers (p NA) The authors investigated the role of aberrant activation of Notch signaling in the pathogenesis of colon cancer. The results indicated that Notch1 signaling positively regulates the growth of colon cancers and that the modulation of Notch1-related signaling may be a promising therapy for human colon cancers. Abstract
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Breast DiseaseHigher parity and shorter breastfeeding duration : Association with triple-negative phenotype of breast cancer (p NA) Findings from a consecutive case series of risk factors and tumor phenotype in 2473 breast cancer patients supported an a priori hypothesis that triple-negative phenotype would be associated with shorter duration of breastfeeding and higher parity, theoretically related to progenitor cell retention within breast tissues. Abstract
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DisciplineOutcomes ResearchDelays in diagnosis and bladder cancer mortality (p NA) To determine whether opportunities for improving bladder cancer outcomes may exist upstream from the diagnosis, the authors used national cancer registry data to measure the relation between a delay in diagnosis and a patient's risk of death. Among patients who had hematuria in the year before their bladder cancer diagnosis, a 9-month delay in diagnosis was associated with a nearly 30% greater risk of death from the disease, independent of cancer grade or stage, compared with patients who were diagnosed within 3 months of their first hematuria claim (adjusted hazard ratio, 1.29 [1.14-1.45]). Abstract
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Translational ResearchDeoxycitidine kinase is associated with prolonged survival after adjuvant gemcitabine for resected pancreatic adenocarcinoma (p NA) Deoxycytidine kinase (dCK) mediates the rate-limiting catabolic step in the activation of gemcitabine. In this study, the authors investigated patient outcomes according to the expression of dCK after postoperative gemcitabine-based chemoradiation. The results indicated that overall survival in patients with resected pancreatic cancer who received adjuvant gemcitabine-based radiochemotherapy depended on dCK protein expression. Abstract
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Disease SiteGastrointestinal DiseaseClinical impact of tumor-infiltrating lymphocytes for survival in stage II colon cancer (p NA) The objective of this study was to assess and compare the prognostic role of tumor-infiltrating lymphocytes (TILs) in stage II colon cancer. The results indicated that TILs may provide a novel, independent predictor of prognosis for patients with early stage colon cancer and may help to identify patients who have an unfavorable prognosis. Abstract
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DisciplineTranslational ResearchGemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer (p NA) The authors demonstrated that polymorphic variants of gemcitabine metabolic and transporter genes are associated with toxicity and treatment efficacy of gemcitabine in patients with locally advanced pancreatic cancer. This information has the potential to be useful in treatment selection and dose management for individualized cancer therapy. Abstract
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Disease SiteGenitourinary DiseaseEvaluation of lymph node counts in primary retroperitoneal lymph node dissection (p NA) In this study, the results suggested that >40 lymph nodes removed at retroperitoneal lymph node dissection (RPLND) for nonseminomatous germ cell tumors improved the diagnostic efficacy of the operation. The authors believe that these results will be useful for future trials comparing RPLNDs, especially when assessing the adequacy of lymph node dissection. Abstract
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CorrespondenceDecreased cancer survival in individuals separated at time of diagnosis: Critical period for cancer pathophysiology? (p NA) Abstract
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Review ArticlesHead and neck cancer : Proteomic advances and biomarker achievements (p NA) This review emphasizes the importance of proteomic tools in understanding head and neck cancer, highlighting proteomic tools used in cancer studies and new findings in head and neck cancer diagnostic and physiological biomarkers. Abstract
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Original ArticlesDisciplineTranslational ResearchDasatinib induces autophagic cell death in human ovarian cancer (p NA) Dasatinib induces autophagic cell death in ovarian cancer that partially depends on beclin 1, AKT, and Bcl-2. These results may have implications for clinical use of dasatinib. Abstract
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Pediatric OncologyThe tyrosine kinase c-Abl promotes proliferation and is expressed in atypical teratoid and malignant rhabdoid tumors (p NA) The current results indicated that c-Abl, a target of tyrosine kinase inhibitors (eg, imatinib), is highly expressed and involved in the biology of malignant rhabdoid tumors. This finding provides a first rationale for targeting c-Abl in malignant rhabdoid tumors. Abstract
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EpidemiologyChildhood cancer mortality in America, Asia, and Oceania, 1970 through 2007 (p NA) From 1970 to 2005, mortality rates for all childhood cancers were halved in North America and in Japan, reaching rates of 3 per 100,000 boys and 2 per 100,000 girls. However, in most Latin American countries and in other middle-income countries during 2005 through 2007, the rates were approximately 5 per 100,000 boys and 4 per 100,000 girls, which were similar to the rates reported in most developed countries during the 1980s. The smaller and later decline in childhood cancer mortality in several middle-income countries reflected delays in the adoption of newer integrated therapies in those countries. Abstract
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Disease SiteBreast DiseaseEvaluation of a breast cancer risk prediction model expanded to include category of prior benign breast disease lesion (p NA) Given the substantial heterogeneity in breast cancer risk dependent on the type of benign lesion, the authors evaluated whether incorporating more detail on the type of histologic lesion improved the discriminatory power of the Rosner-Colditz breast cancer risk prediction model in the Nurses' Health Study. The results indicated that including the histologic classification of benign breast lesion significantly improved the risk prediction model. Abstract
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Hepatobiliary DiseasePhase 1-2 trial of PTK787/ZK222584 combined with intravenous doxorubicin for treatment of patients with advanced hepatocellular carcinoma : Implication for antiangiogenic approach to hepatocellular carcinoma (p NA) The combination of PTK787 and doxorubicin shows encouraging activity in advanced hepatocellular carcinoma patients. Thus, the idea of combining an antiangiogenic agent together with chemotherapy warrants further evaluation in future clinical trials. Abstract
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DisciplineDisparities ResearchAfrican ancestry and higher prevalence of triple-negative breast cancer : Findings from an international study (p NA) Estrogen receptor-negative and triple-negative breast cancer is more common in African American compared with white/European American women. This international study involving Ghana suggests that African ancestry may predispose to high-risk breast tumors. Abstract
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Review ArticlesBRAF, a target in melanoma : Implications for solid tumor drug development (p NA) Mutation of v-raf murine sarcoma viral oncogene homolog B1 (BRAF), a serine/threonine kinase, has been validated as a therapeutic target in patients with melanoma. Defining the value of BRAF inhibition in other solid tumors that harbor BRAF is the current priority. Abstract
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Original ArticlesDisciplineRadiation OncologySequential magnetic resonance imaging of cervical cancer : The predictive value of absolute tumor volume and regression ratio measured before, during, and after radiation therapy (p NA) In this study, the authors investigated the efficacy of outcome prediction using serial magnetic resonance imaging examinations to measure both tumor volumes and regression ratios before, during, and after radiotherapy and developed algorithms to identify early those patients with cervical cancer who were at risk of treatment failure. Abstract
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Disease SiteLung DiseaseFactors associated with the development of brain metastases : Analysis of 975 patients with early stage nonsmall cell lung cancer (p NA) The actuarial risk of developing brain metastases in early stage NSCLC is 10%. Risk factors include younger age, larger tumor size, lymphovascular space invasion, and hilar lymph node involvement. Abstract
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Genitourinary DiseaseChromosome 9p deletions identify an aggressive phenotype of clear cell renal cell carcinoma (p NA) The results from this study indicated that chromosome 9p deletions are associated with aggressive clear cell renal cell carcinomas, even in otherwise indolent-appearing lesions. These deletions can be detected preoperatively and may help individualize the treatment approach. Abstract
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Hematologic MalignanciesAdult patients with acute myeloid leukemia who achieve complete remission after 1 or 2 cycles of induction have a similar prognosis : A report on 1980 patients registered to 6 studies conducted by the Eastern Cooperative Oncology Group (p NA) For patients with newly diagnosed acute myeloid leukemia, the presence of residual leukemia in bone marrow 10 to 14 days after the start of induction therapy did not predict a worse prognosis if a second, similar cycle of induction therapy was administered and if complete remission was achieved. Abstract
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Gynecologic OncologyA double-blind, randomized trial of pyridoxine versus placebo for the prevention of pegylated liposomal doxorubicin-related hand-foot syndrome in gynecologic oncology patients (p NA) In patients who received pegylated liposomal doxorubicin, there was no difference in the incidence of hand-foot syndrome (HFS) in those who were assigned randomly to receive pyridoxine versus placebo. Pyridoxine at the dose level in the current study is not indicated for the prevention of HFS during chemotherapy. Abstract
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DisciplineOutcomes ResearchBreastfeeding in survivors of Hodgkin lymphoma treated with chest radiotherapy (p NA) Analysis of self-reported breastfeeding success in women who were long-term survivors after chest radiotherapy for Hodgkin lymphoma was preformed. The majority of Hodgkin lymphoma survivors who were treated with chest radiotherapy were able to breastfeed, although at a slightly decreased frequency compared with their sibling controls. Abstract
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Disease SiteGastrointestinal DiseaseCritical role of surgery in patients with gastroesophageal carcinoma with a poor prognosis after chemoradiation as defined by positron emission tomography (p NA) The prognosis of patients with localized gastroesophageal carcinoma can be defined after chemoradiation by the standardized uptake value (SUV) of positron emission tomography. In the current study, the authors retrospectively examined the role of surgery in patients with a high SUV after chemoradiation. Surgery was found to prolong survival in patients with esophageal cancer. Abstract
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DisciplinePediatric OncologyComplementary therapies for children undergoing stem cell transplantation : Report of a multisite trial (p NA) Children scheduled to undergo stem cell transplantation (SCT) (N = 178) participated in a randomized trial of complementary therapies (massage, humor, relaxation/imagery) designed to reduce transplant-related distress. No significant differences between treatment arms were found by patient and parent report, nor on relevant medical outcomes. Results of this multisite trial failed to document significant benefits of complementary interventions in the pediatric SCT setting. Abstract
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Disparities ResearchRacial disparities in colorectal cancer survival : To what extent are racial disparities explained by differences in treatment, tumor characteristics, or hospital characteristics? (p NA) For patients with colorectal cancer (CRC), comorbidities and socioeconomic status (SES) appeared to be more important factors contributing to poorer survival among black patients relative to white and Asian patients. However, racial/ethnic disparities in CRC survival were not fully explained by differences in tumor characteristics, comorbidities, screening, treatment, and SES. Abstract
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Disease SiteLung DiseaseHigh rates of tumor growth and disease progression detected on serial pretreatment fluorodeoxyglucose-positron emission tomography/computed tomography scans in radical radiotherapy candidates with nonsmall cell lung cancer (p NA) The authors studied growth and progression of untreated nonsmall cell lung cancer by comparing diagnostic and radiotherapy (RT) planning fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography scans before proposed radical chemo-RT. Interscan disease progression occurred in 39% of patients, 28% were unsuitable for radical therapy after the second PET scan, and the estimated doubling time of FDG avid tumor was only 66 days. Abstract
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EditorialsQuestions regarding frontline therapy of acute myeloid leukemia (p NA) The results from multiple investigations using different induction approaches suggest that better regimens are available and should be investigated further in the context of acute myeloid leukemia (AML) heterogeneity and emerging prognostic knowledge concerning cytogenetic and molecular abnormalities. Today, based on existing data, evaluating bone marrow on Days 10 to 14 for residual AML and reacting to the bone marrow findings may be a common practice, but is not validated by objective data. Abstract
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CorrespondenceReply to Decreased cancer survival in individuals separated at time of diagnosis: Critical period for cancer pathophysiology? (p NA) Abstract
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Decreased cancer survival in individuals separated at time of diagnosis: Critical period for cancer pathophysiology? (p NA) Abstract
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Original ArticlesDisease SiteBreast DiseaseFive-year outcome of patients classified using the American Society for Radiation Oncology consensus statement guidelines for the application of accelerated partial breast irradiation : An analysis of patients treated on the American Society of Breast Surgeons MammoSite Registry Trial (p NA) When it was applied to patients who were treated on the American Society of Breast Surgeons MammoSite Registry Trial, the American Society for Radiation Oncology consensus statement for the use of accelerated partial breast irradiation did not differentiate a subset of patients with a significantly worse rate of ipsilateral breast tumor recurrence. Abstract
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DisciplineDisparities ResearchOhio Appalachian women's perceptions of the cost of cervical cancer screening (p NA) The current study explored the expectations of women in Appalachian Ohio regarding Papanicolaou (Pap) test costs and perceptions of cost as a barrier to screening. Women who noted cost as a barrier were twice as likely to not receive a test within screening guidelines as those who did not perceive a cost barrier, but >80% of women reported not knowing the cost of a Pap test. Abstract
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Disease SiteLung DiseaseHealthcare use after screening for lung cancer (p NA) Healthcare use is reported to increase in the 6 months after lung cancer screening. This is true for individuals with a negative screening result as well as for those with a false-positive result. Abstract
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DisciplineEpidemiologyTrends in incidence and survival of pediatric and adolescent patients with germ cell tumors in the United States, 1975 to 2006 (p NA) No significant differences in incidence rates by race or ethnicity were observed in children diagnosed between birth and 9 years of age; however, statistically significant differences were observed in adolescents diagnosed between ages 10 and 19 years. This analysis of the Surveillance, Epidemiology, and End Results data suggested that the incidence of germ cell tumors may be increasing in young girls (birth to 9 years of age) in addition to the well-documented increase in adolescent males (ages 10-19 years). Abstract
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Review ArticlesDevelopment of curcumin as an epigenetic agent (p NA) Clinically achievable plasma concentrations of curcumin in humans are much lower than those in in vitro studies. Thus, novel mechanisms of curcumin for cancer treatment as an epigenetic agent should be delineated to facilitate its future development. Abstract
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Original ArticlesDisciplineEpidemiologyLung cancer histology, stage, treatment, and survival in American Indians and Alaska Natives and whites (p NA) Lung cancer histology was found to be associated with tumor characteristics, treatment, and survival. In this analysis of lung cancer cases in the Surveillance, Epidemiology, and End Results (SEER) program, American Indians and Alaska Natives were found to have different lung cancer histology distribution, a reduced likelihood of receiving surgery, and an increased risk of death compared with whites. Abstract
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Disease SiteLung DiseasePeak oxygen consumption and long-term all-cause mortality in nonsmall cell lung cancer (p NA) Identifying strong markers of prognosis is critical to optimize treatment and survival outcomes in patients with nonsmall cell lung cancer (NSCLC). Here, the authors observed that peak oxygen consumption is a strong independent predictor of survival in NSCLC that may complement traditional markers of prognosis. Abstract
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ChestInsulin-like growth factor-1 receptor and phosphorylated AKT-serine 473 expression in 132 resected thymomas and thymic carcinomas (p NA) The authors conducted a retrospective analysis of 132 patients with thymic epithelial malignancies who underwent surgery at a single institution. The results indicated that insulin-like growth factor-1 receptor (IGF-1R) and phosphorylated AKT-serine 473 are expressed commonly in these tumors and are more frequent in aggressive tumors, suggesting that IGF-1R may play a role in thymic malignancies and may be a potential target for treatment. Abstract
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Hematologic MalignanciesReactivation of hepatitis B virus after rituximab-containing treatment in patients with CD20-positive B-cell lymphoma (p NA) This paper describes the incidence and risk factors for HBV reactivation after the use of rituximab in hepatitis B surface antigen-negative patients with CD20-positive B-cell lymphomas. The authors found that patients positive for antibody to hepatitis B core antigen, especially those who were negative for antibody to hepatitis B surface antigen, were at high risk for developing HBV reactivation after treatment with rituximab-containing therapy. Abstract
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Hairy cell leukemia : Evaluation of the long-term outcome in 121 patients (p NA) This study confirms the high risk of retreatment of hairy cell leukemia patients and the need to maximize primary response, including the possibility of combining purine analogues with rituximab or other monoclonal antibodies. Abstract
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DisciplineDisparities ResearchData and trends in cancer screening in the United States : Results from the 2005 National Health Interview Survey (p NA) On examination of cancer screening in the 2005 National Health Interview Survey, large gaps in use remain among population groups with differing levels of education, income, usual source of care, health insurance, and recent physician contact. Results identify specific populations that may benefit from efforts to overcome barriers to screening. Abstract
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Disease SiteGenitourinary DiseaseBaseline PSA as a predictor of prostate cancer-specific mortality over the past 2 decades : Duke university experience (p NA) Baseline prostate-specific antigen (PSA) appears to be an accurate and independent predictor of death from prostate cancer. A baseline PSA of Abstract
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DisciplinePediatric OncologyProspective collection of tissue samples at autopsy in children with diffuse intrinsic pontine glioma (p NA) Brain tissue obtained at autopsy has been used in research for non-oncologic disorders. However, to our knowledge, this tool has never been used before for large investigational studies focused on cancer. In the current study, the authors demonstrated that DNA and RNA suitable for sophisticated genome-wide studies can be successfully obtained in multicenter biological studies based on tissue obtained at autopsy in children with diffuse intrinsic pontine glioma, a deadly pediatric brain cancer. Abstract
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Psychosocial OncologyParental cancer and the family : A population-based estimate of the number of US cancer survivors residing with their minor children (p NA) The authors estimate that 18% of newly diagnosed survivors and 14% of all US cancer survivors reside with 1 or more of their children younger than 18 years of age. This represents a population of 1.58 million survivors and 2.85 million children for whom cancer may pose special challenges and who may require additional resources. Abstract
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Disease SiteLung DiseaseDose escalation of gemcitabine concomitant with radiation and cisplatin for nonsmall cell lung cancer : A phase 1-2 study (p NA) Gemcitabine at doses up to 550 mg/m2 weekly can be given simultaneously with radiation and cisplatin to patients with locally advanced nonsmall cell lung cancer. Radical resection thereafter is feasible. The impact of this aggressive therapy should be evaluated further. Abstract
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Head and Neck DiseaseImproved survival is associated with treatment at high-volume teaching facilities for patients with advanced stage laryngeal cancer (p NA) In this study, the authors observed that receiving treatment at high-volume teaching/research facilities was associated with improved survival. Undergoing total laryngectomy also was associated with improved survival. Abstract
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EditorialsA population-based estimate of cancer survivors residing with minor children (p NA) A new approach is needed to address the concerns of 1.5 million cancer patients parenting nearly 3 million minor children. Principles from a parent-guidance program are offered to support families in cancer care settings with various levels of clinical resources. Abstract
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Original ArticlesDisease SiteGenitourinary DiseaseAge at diagnosis and the utility of prognostic testing in patients with chronic lymphocytic leukemia (p NA) Among patients aged <75 years, the simple combinations of stage and IGHV mutation status or stage and fluorescent in situ hybridization identifies those with excess risk of death relative to the age-matched population. Although useful for predicting time to first treatment independent of stage for patients of all ages, prognostic testing had little utility for predicting overall survival independent of stage among patients aged Abstract
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Gynecologic OncologyEpithelial membrane protein-2 expression is an early predictor of endometrial cancer development (p NA) Detailed analysis of EMP2 expression in preneoplastic lesions showed that EMP2 positivity was a strong predictor for endometrial cancer (EC) development. As EMP2 expression has already been shown to correlate with aggressive EC, these results confirm that EMP2 is a novel biomarker for future hyperplasia progression to EC development. Abstract
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DisciplineDisparities ResearchCharacteristics of patients with stage III colon adenocarcinoma who fail to receive guideline-recommended treatment (p NA) The authors investigated the proportion of patients with stage III colon adenocarcinoma who did not receive treatment according to evidence-based guidelines in Alberta, Canada and observed that it was appreciable. The results indicated that association between this failure and patient age, geography, and income is concerning. Abstract
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Disease SiteGenitourinary DiseaseRegional variation in cancer-directed surgery and mortality among women with epithelial ovarian cancer in the medicare population (p NA) The authors investigated regional variation in mortality among Medicare recipients with ovarian cancer, and access to cancer-directed surgery explained some of this variation. The results indicated that improving access to high-quality cancer surgery for ovarian cancer may improve outcomes, particularly for minorities and for older women. Abstract
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Testicular microlithiasis predicts concurrent testicular germ cell tumors and intratubular germ cell neoplasia of unclassified type in adults : A meta-analysis and systematic review (p NA) Testicular microlithiasis is a marker of risk of concurrent germ cell tumors and intratubular germ cell neoplasia of unclassified type. These risks should be considered in the clinical management of patients with testicular microlithiasis. Abstract
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Underuse of colorectal cancer screening among men screened for prostate cancer : A teachable moment? (p NA) One half of the participants who attended free prostate cancer screening programs were eligible for but not adherent to colorectal cancer screening. Free prostate cancer screening programs may provide a teachable moment to increase colorectal cancer screening at a time when men are receptive to cancer screening messages. Abstract
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Lung DiseaseUp-regulation of interleukin-17 expression by human papillomavirus type 16 E6 in nonsmall cell lung cancer (p NA) Interleukin (IL)-17 expression is significantly associated with human papillomavirus (HPV) infection in nonsmall cell lung cancer tissues. This study suggests that HPV infection-induced IL-17 level can stimulate Mcl-1 expression through the PI3K pathway and promote lung tumor cell progression through a p53- and IL-6-independent pathway. Abstract
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Breast DiseaseUtility of the GeneSearch breast lymph node assay for the rapid evaluation of sentinel lymph nodes in breast cancer (p NA) Half of each sentinel lymph node from 117 breast cancer patients was examined by a real-time reverse transcriptase-polymerase chain reaction assay using 2 markers. This assay may be a more accurate diagnostic tool compared with current pathologic examination. Abstract
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Genitourinary DiseaseA multiplexed, particle-based flow cytometric assay identified plasma matrix metalloproteinase-7 to be associated with cancer-related death among patients with bladder cancer (p NA) Multiplexed, particle-based flow cytometric assay allows for high-throughput measurement of multiple plasma or serum proteins simultaneously. By using this new technology in a cohort of patients with bladder cancer, the authors identified plasma levels of matrix metalloproteinase-7 to be significantly associated with time to cancer-related death. Abstract
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Breast DiseaseFactors associated with low screening for breast cancer in the Palestinian authority : Relations of availability, environmental barriers, and cancer-related fatalism (p NA) This is the first study among Palestinian women in the West Bank on breast cancer screening. Rates of mammography and clinical breast examination attendance were very low, whereas a relatively high percentage of the women performed self breast examinations, probably because of low access to mammography and clinical breast examination. Cancer fatalism, higher religiosity, and lower education predicted lower performance of examinations. Abstract
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Hematologic MalignanciesInterim report of a phase 2 clinical trial of lenalidomide for T-cell non-Hodgkin lymphoma (p NA) We report the interim results of a prospective multicenter phase 2 trial evaluating lenalidomide in recurrent and refractory T-cell lymphoma. Patients were prescribed oral lenalidomide on Days 1 to 21 of each 28-day cycle, and the primary endpoint of overall response rate was 7 (30%) of 23. Abstract
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Neuro-OncologyCharacteristics and outcomes of elderly patients with primary central nervous system lymphoma : The Memorial Sloan-Kettering Cancer Center experience (p NA) Approximately half of all patients with primary central nervous system lymphoma (PCNSL) are aged Abstract
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EditorialUnderstanding social obstacles to early breast cancer detection is critical to improving breast cancer outcome in low- and middle-resource countries (p NA) In low- and middle-resource countries worsened cancer survival is attributable largely to late-stage presentation, which leads to particularly poor outcome when coupled with limited diagnostic and treatment capacity. The identification of social obstacles linked to public awareness programs educating women that breast cancer outcomes are improved through early detection is critical to broadening participation in early detection programs. Abstract
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Original ArticlesDisease SiteHematologic MalignanciesClinical utility of multiparameter flow cytometry in the diagnosis of 1013 patients with suspected myelodysplastic syndrome : Correlation to cytomorphology, cytogenetics, and clinical data (p NA) The diagnostic use of multiparameter flow cytometry (MFC) in patients with suspected myelodysplasia was analyzed and compared using cytomorphology and cytogenetics. The results indicated that MFC is capable of providing important additional information. Abstract
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Breast DiseaseInvasive neuroendocrine carcinoma of the breast : A distinctive subtype of aggressive mammary carcinoma (p NA) Neuroendocrine carcinoma is a distinct type of aggressive mammary carcinoma. Novel therapeutic approaches should be explored for this uniquely different clinical entity. Abstract
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Hematologic MalignanciesActivity and tolerability of nilotinib : A retrospective multicenter analysis of chronic myeloid leukemia patients who are imatinib resistant or intolerant (p NA) Nilotinib is an effective and safe treatment for chronic myeloid leukemia patients who are imatinib resistant or intolerant. Prior response to imatinib is predictive of the response to nilotinib. Abstract
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DisciplineClinical TrialsLong-term results of a phase 2 study of neoadjuvant chemotherapy and radiotherapy in the management of high-risk, high-grade, soft tissue sarcomas of the extremities and body wall : Radiation Therapy Oncology Group Trial 9514 (p NA) Sixty-four patients were managed with neoadjuvant mesna, doxorubicin, ifosfamide, and dacarbazine chemotherapy; radiation; resection; and adjuvant mesna, doxorubicin, ifosfamide, and dacarbazine chemotherapy for advanced high-grade extremity and torso soft tissue sarcomas. Although toxic, this long-term analysis demonstrates results somewhat better than might be expected for such high-risk tumors. Abstract
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Disease SiteGastrointestinal DiseaseRelation between normal rectal methylation, smoking status, and the presence or absence of colorectal adenomas (p NA) A prediction model was developed for the presence of colorectal adenomas based on gene methylation patterns in the normal rectum. The results indicated that normal rectal methylation may be useful as a biomarker for narrowing the population in greatest need of screening colonoscopy. Abstract
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DisciplinePediatric OncologyAttention and working memory abilities in children treated for acute lymphoblastic leukemia (p NA) Survivors of childhood acute lymphoblastic leukemia demonstrate working memory abilities that appear to be statistically lower than healthy peers and clinically fall below the average range. Working memory abilities are more sensitive to treatment effects than attention, make a unique contribution to intelligence, and are associated with cerebral white matter changes. Abstract
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Clinical TrialsAnthracycline dose intensification in adult acute lymphoblastic leukemia : Lack of benefit in the context of the fractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone regimen (p NA) Sixty-eight patients with newly diagnosed acute lymphoblastic leukemia or lymphoblastic lymphoma received the hyper-CVAD regimen (hyper-fractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone alternating with high dose methotrexate and cytarabine) with the addition of high-dose liposomal daunorubicin as postremission consolidation therapy (Course 2). The incorporation of early anthracycline intensification did not improve outcome. Abstract
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Disease SiteHead and Neck DiseaseEfficacy and toxicity of reirradiation using intensity-modulated radiotherapy for recurrent or second primary head and neck cancer (p NA) Optimal management of recurrent head and neck cancer involves surgical resection followed by adjuvant chemoradiotherapy. The results of the current study showed that reirradiation with intensity-modulated radiotherapy is feasible and associated with high locoregional control rates but also is associated with significant grade 3 or higher acute and late toxicity. Abstract
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DisciplinePathologyExpression of p16 in lymph node metastases of adjuvantly treated stage III colorectal cancer patients identifies poor prognostic subgroups : A retrospective analysis of biomarkers in matched primary tumor and lymph node metastases (p NA) The objective of identifying protein biomarkers for patients with stage III colorectal cancer is to improve risk stratification and, thus, to identify patients in the postoperative setting who may benefit from a more targeted treatment. In this study, the authors demonstrated that, in patients who received adjuvant treatment for stage III colorectal cancer, negative expression of p16 in lymph node metastases had a highly negative impact on overall survival independent of pathologic tumor classification, age, or lymph node ratio, supporting the investigation of this biomarker in future prognostic and predictive studies. Abstract
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Symptom Control and Palliative CarePredictors of anticoagulation in hospice patients with lung cancer (p NA) Guidelines recommend lifelong anticoagulation in patients with cancer and thromboembolism, but the benefits and risks of anticoagulation in an end-of-life population are unclear. In this study, 1 of every 11 hospice patients with lung cancer was prescribed an anticoagulant, most commonly warfarin, and patients who were older and had a longer stay in hospice were more likely to be prescribed warfarin compared with low molecular weight heparin. Abstract
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Disease SiteHepatobiliary DiseaseEarly alpha-fetoprotein response predicts treatment efficacy of antiangiogenic systemic therapy in patients with advanced hepatocellular carcinoma (p NA) Antiangiogenic therapy is the current standard therapy for patients with advanced hepatocellular carcinoma. In this study, the authors demonstrated that an early alpha-fetoprotein response predicted better response and disease-control rates and longer progression-free and overall survival in these patients. Abstract
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Review ArticlesTranslating research into evidence-based practice : The National Cancer Institute Community Clinical Oncology Program (p NA) The National Institutes of Health and other programs are increasingly emphasizing research that involves evidence development, comparative effectiveness, translational research, and accelerating the translation of research into evidence-based practice as well as building successful research networks to support these efforts. In this review, the authors describe the National Cancer Institute Community Clinical Oncology Program and its history of successfully extending research into the community, facilitating the translation of research into practice, and providing practical guidance to provider-based research networks in cancer and other disciplines. Abstract
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Original ArticlesDisease SiteLung DiseaseThe antitumor activity of NK012, an SN-38-incorporating micelle, in combination with bevacizumab against lung cancer xenografts (p NA) The combination of NK012 (a novel 7-ethyl-10-hydroxycamptothecin [SN-38]-incorporating polymeric micelle) with bevacizumab produced significantly greater antitumor activity against human lung cancer xenografts compared with NK012 alone. The pharmacokinetic profile of NK012 revealed that the coadministration of bevacizumab did not interfere with the accumulation of NK012 in tumors. Abstract
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DisciplineOutcomes ResearchInfluence of patients' preferences and treatment site on cancer patients' end-of-life care (p NA) Research suggests that patients' end-of-life care is determined primarily by the medical resources available and not by patient preferences. In this multisite, prospective, longitudinal cohort study, the authors observed that patients with advanced cancer who wanted life-extending care were 3 times more likely to receive cardiopulmonary resuscitation and/or mechanical ventilation and to die in an intensive care unit, independent of treatment site. Abstract
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Disease SiteHematologic MalignanciesOxaliplatin-based chemotherapy (dexamethasone, high-dose cytarabine, and oxaliplatin) ± rituximab is an effective salvage regimen in patients with relapsed or refractory lymphoma (p NA) The study assessed the efficacy and safety of dexamethasone, high-dose cytarabine, and oxaliplatin as salvage therapy in lymphoma patients, replacing cisplatin with oxaliplatin in the standard dexamethasone, cytarabine, and cisplatin scheme. It confirmed that dexamethasone, high-dose cytarabine, and oxaliplatin ± rituximab is an effective and feasible outpatient regimen for salvage therapy in patients affected by relapsed or refractory lymphoma. Moreover, the feasibility and efficacy of this scheme as an in vivo chemosensitive test in patients in autotransplantation programs was confirmed. Abstract
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DisciplineRadiation OncologyConcomitant weekly cisplatin and altered fractionation radiotherapy in locally advanced head and neck cancer (p NA) The authors reported efficacy and toxicity after weekly cisplatin (30 mg/m2/wk) concurrent with altered fractionation radiotherapy (RT). Concomitant weekly cisplatin with altered fractionation RT is a safe and effective treatment regimen. Abstract
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Disease SiteGenitourinary DiseasePrognostic impact of plasminogen activator inhibitor type 1 expression in bladder cancer (p NA) The prognostic impact of plasminogen activator inhibitor type 1 (PAI-1) was investigated in patients with bladder cancer. The results indicated that immunohistochemical detection of single PAI-1-positive cells may serve as a predictor of survival and a possible indicator of metastasis in these patients. Abstract
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DisciplinePediatric OncologyInitial response to salvage therapy determines prognosis in relapsed pediatric Hodgkin lymphoma patients (p NA) The authors investigated the prognostic significance of the initial response to salvage therapy in pediatric patients with relapsed Hodgkin lymphoma (HL). The results indicated that pediatric patients with relapsed HL who have an inadequate response after initial primary salvage chemotherapy have a very poor prognosis and should be considered for novel therapies directed at biologic or immunologic targets. Abstract
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Disease SiteBreast DiseaseThe impact of a national program to provide free mammograms to low-income, uninsured women on breast cancer mortality rates (p NA) The authors examined the impact of a state-level program that provides free mammograms to low-income women on breast cancer mortality rates. Some of the evidence suggested that the National Breast and Cervical Cancer Early Detection Program led to a reduction in breast cancer mortality rates. Abstract
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Lung DiseaseCombination of low vascular endothelial growth factor A (VEGF-A)/VEGF receptor 2 expression and high lymphocyte infiltration is a strong and independent favorable prognostic factor in patients with nonsmall cell lung cancer (p NA) There is a close interplay between angiogenesis and the immune system. The authors of this report investigated for the first time the combination of angiogenic markers with in situ immunity markers and observed that this coexpression had an independent prognostic impact on nonsmall cell lung cancer. Abstract
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Hematologic MalignanciesMarginal zone lymphomas : Factors that affect the final outcome (p NA) Patients with extranodal and nodal marginal zone lymphoma (MZL) have a similar prognosis, whereas patients with splenic MZL have a comparatively better prognosis. Three factors, B symptoms, Abstract
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DisciplineTranslational ResearchAdenovirus-mediated expression of truncated E2F-1 suppresses tumor growth in vitro and in vivo (p NA) The authors constructed an adenovirus (Ad) vector that expressed the truncated form of the E2F-1 gene (E2Ftr) under regulation of the tetracycline (Tet)-off system (AdTet-E2Ftr3). The results demonstrated that this vector is a novel anticancer agent with significant therapeutic activity in vitro and in vivo. AdTet-E2Ftr3 induced apoptosis in cancer cells independent of p53 status with low cytotoxicity in normal cells. Abstract
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Pediatric OncologySecondary hematopoietic malignancies in survivors of childhood cancer : An analysis of 111 cases from the Surveillance, Epidemiology, and End Result-9 registry (p NA) The Surveillance, Epidemiology, and End Result-9 registry was analyzed for incidence, histological subtypes, risk factors, outcomes, and changing risk trends of secondary malignancies in 111 survivors of childhood cancer. Survivors of childhood cancer are at increased risk of developing secondary hematological malignancies, particularly secondary acute myeloid leukemia; close long-term monitoring in these patients is warranted. Abstract
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Disease SiteBreast DiseaseDifferential response of triple-negative breast cancer to a docetaxel and carboplatin-based neoadjuvant treatment (p NA) The results from this study indicated that differential tumor response to neoadjuvant therapy among patients with similar stage of breast cancer may aid in developing tailored therapy and identifying new targets for drug-resistant tumors. Abstract
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Hematologic MalignanciesEfficacy and safety of the combination of rituximab, fludarabine, and mitoxantrone for rituximab-naive, recurrent/refractory follicular non-Hodgkin lymphoma with high tumor burden : A multicenter phase 2 trial by the Groupe d'Etude des Lymphomes de l'Adulte (GELA) and Groupe Ouest Est des Leucémies et Autres Maladies du Sang (GOELAMS) (p NA) To the authors' knowledge, this is the first report of efficacy and safety findings from the combination of rituximab, fludarabine, and mitoxantrone (R-FM) in patients with recurrent/refractory follicular lymphoma who were selected on the basis of high tumor burden criteria at study entry. The results indicated that a 4-course R-FM induction was safe and yielded high overall and complete response rates. Abstract
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MelanomaPrognostic factors for melanoma in children and adolescents : A clinicopathologic, single-center study of 137 Patients (p NA) In this retrospective, observational study, the authors investigated the prognostic significance of clinical and pathologic findings from 137 children with melanoma. The results indicated that Breslow thickness predicted an increased risk of metastases, whereas age and metastases at diagnosis predicted an increased risk of death. Abstract
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DisciplineClinical TrialsPhase 3 trial of everolimus for metastatic renal cell carcinoma : Final results and analysis of prognostic factors (p NA) Final results and prognostic factor analysis of a phase 3 trial assessing everolimus in patients with metastatic renal cell cancer who progressed on sorafenib and/or sunitinib are reported. Median progression-free survival was 4.9 months with everolimus versus 1.9 months with placebo by independent central review. Survival was 1.9-fold longer with everolimus compared with placebo after correcting for 80% of patients in the placebo arm who crossed over to everolimus, using a rank-preserving structural failure time model. Independent prognostic factors for shorter overall survival included low performance status, high corrected calcium, low hemoglobin, and prior sunitinib. Abstract
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Disease SiteLung DiseaseEpidermal growth factor receptor mutations detected by denaturing high-performance liquid chromatography in nonsmall cell lung cancer : Impact on response to therapy with epidermal growth factor receptor-tyrosine kinase inhibitors (p NA) Epidermal growth factor receptor (EGFR) mutation testing using denaturing high-performance liquid chromatography can be incorporated into the routine care of lung cancer patients. Clinical differences might exist between exon 19 deletions and L858R EGFR mutations in nonsmall cell lung cancer. Abstract
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Gastrointestinal DiseaseSERPINE1 intron polymorphisms affecting gene expression are associated with diffuse-type gastric cancer susceptibility (p NA) A genetic association between SERPINE1 (serpin peptidase inhibitor, clade E, member 1) (a gene that encodes plasminogen activator inhibitor 1) and diffuse-type gastric cancer was discovered. The association was observed with 4 correlated variations in intron 7 that affected SERPINE1 expression rather than with the promoter 4G/5G polymorphism. Abstract
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MelanomaCorrelation of molecular human leukocyte antigen typing and outcome in high-risk melanoma patients receiving adjuvant interferon (p NA) In this prospective analysis, which was performed to evaluate whether human leukocyte antigen (HLA) phenotype influences the likelihood of a favorable outcome or response, the presence of HLA-Cw*06 allele was associated with better relapse-free and overall survival and the appearance of autoimmunity. The Cw*06 allele has been correlated with psoriasis. These results, if validated in trials of adjuvant interferon conducted in separate US and European cooperative groups, could be used to identify patients who would benefit from adjuvant interferon. Abstract
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CorrespondenceFalse-positivity in the sentinel lymph nodes in melanoma and breast cancer (p NA) Abstract
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Reply to False-positivity in the sentinel lymph nodes in melanoma and breast cancer (p NA) Abstract
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Original ArticlesDisease SiteBreast DiseaseBreast cancer subtypes and response to systemic treatment after whole-brain radiotherapy in patients with brain metastases (p NA) Systemic therapy, sequenced by whole-brain radiotherapy (WBRT), was found to improve survival in patients with breast cancer of luminal A, luminal B, and human epidermal growth factor receptor 2 (HER2) subtypes with brain metastases. Targeted therapy appears to have an additional positive impact on survival. In triple-negative breast cancer subsets, the role of systematic treatment after WBRT appears to be less clear; therefore, this issue required further investigation. Abstract
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DisciplineSymptom Control and Palliative CareA prospective study of aromatase inhibitor-associated musculoskeletal symptoms and abnormalities on serial high-resolution wrist ultrasonography (p NA) Clinically relevant musculoskeletal symptoms develop in women treated with adjuvant aromatase inhibitors, leading to treatment discontinuation in a substantial percentage. The upper extremities are frequently affected, especially the wrists, hands, and fingers. In this pilot study, no statistically significant association was found between patient-reported musculoskeletal symptoms and abnormalities detected with wrist ultrasonography. Abstract
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EpidemiologyTelomere length and genetic analyses in population-based studies of endometrial cancer risk (p NA) Relative telomere length was not associated with endometrial cancer risk in this prospective population-based study. Elevated endometrial cancer risk associated with polymorphisms at telomere maintenance gene loci suggests that other aspects of telomere dynamics may be involved in endometrial carcinogenesis. Abstract
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Disease SiteHead and Neck DiseaseGenetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck (p NA) Single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) may alter the processing, transcription, and expression of miRNAs and, thus, may contribute to cancer development. The authors of this report hypothesized that common polymorphisms in pre-miRNAs are associated individually and (more likely) collectively with the risk of squamous cell carcinoma of the head and neck (SCCHN). The results indicated that the combined risk genotypes of 4 common SNPs in pre-miRNAs were associated significantly with a moderately increased risk of SCCHN. Abstract
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DisciplineDisparities ResearchInsurance status and survival disparities among nonelderly rectal cancer patients in the National Cancer Data Base (p NA) After adjustment for age, further adjustment for 9 other factors reduced the excess mortality among rectal cancer patients without private insurance by approximately 70%. Disparities in stage and treatment accounted for approximately 53% of the excess mortality, whereas factors other than stage and treatment accounted for approximately 17%. Abstract
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CommentariesHuman papillomavirus status in head and neck cancer : The ethics of disclosure (p NA) Human papillomavirus (HPV) is an emerging causative factor for squamous cell carcinoma of the head and neck. This paper discusses the ethical issues involved with informing head and neck cancer patients of their HPV status, recognizing the dilemma posed by unresolved clinical questions and the need to respect patient autonomy. Abstract
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Original ArticlesDisciplineEpidemiologyNeighborhood socioeconomic status and behavioral pathways to risks of colon and rectal cancer in women (p NA) Living in a richer neighborhood may protect against rectal cancer in women and colon cancer in higher-educated women. These associations may be mediated by behavioral risk factors including body mass index. Abstract
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Disease SiteGastrointestinal DiseasePhase 2 trial of preoperative irinotecan plus cisplatin and conformal radiotherapy, followed by surgery for esophageal cancer (p NA) This phase 2 trial assessed the feasibility and efficacy of trimodality therapy for esophageal cancer patients. Induction irinotecan/cisplatin chemotherapy concurrent with radiotherapy followed by esophagectomy was associated with an early improvement in dysphagia, a significant but manageable toxicity profile, and encouraging survival compared with historic controls. Abstract
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Lung DiseaseCorrelation of [18F]-2-fluoro-deoxy-D-glucose positron emission tomography standard uptake values with the cellular composition of stage I nonsmall cell lung cancer (p NA) Stage I nonsmall cell lung cancers are histologically heterogeneous, comprised of many cell types, including tumor and inflammatory cells. However, there appears to be no statistically significant correlation between a specific tumor cellular component and [18F]-2-fluoro-deoxy-D-glucose (FDG) activity. Abstract
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DisciplinePsychosocial OncologyDiurnal cortisol dysregulation, functional disability, and depression in women with ovarian cancer (p NA) Dysregulations in diurnal cortisol levels were observed in ovarian cancer patients and were associated with greater functional disability and fatigue but not with life stress or depressed affect. Abstract
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Disease SiteHematologic MalignanciesIntravenous methotrexate as central nervous system (CNS) prophylaxis is associated with a low risk of CNS recurrence in high-risk patients with diffuse large B-cell lymphoma (p NA) Central nervous system (CNS) disease recurrence in patients with diffuse large B-cell lymphoma is a rare but devastating event. This article reports that intravenous methotrexate can be safely administered concurrently with cyclophosphamide, doxorubicin, vincristine, and prednisone with rituximab (R-CHOP) and is associated with decreased risk of CNS recurrence in high-risk patients. Abstract
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CommentariesThe integrity of authorship : Doing the right thing (p NA) Conflicts of interest with regard to peer-reviewed publications are a matter of increasing concern. The authors examined the balance between industry support of a publication and the integrity of authorship. Abstract
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Original ArticlesDisease SiteLung DiseaseRelationship between cytokine gene single nucleotide polymorphisms and symptom burden and quality of life in lung cancer survivors (p NA) The goal of this study was to examine whether cytokine gene single nucleotide polymorphisms (SNPs) were associated with quality of life (QOL) and symptom burden in a large sample of Caucasian lung cancer survivors. Significant associations were found with cytokine gene SNPs and pain, fatigue, appetite, dyspnea, hemoptysis, and QOL. Abstract
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Gynecologic OncologyA phase 1 and pharmacodynamic study of decitabine in combination with carboplatin in patients with recurrent, platinum-resistant, epithelial ovarian cancer (p NA) Based on preclinical studies indicating that hypomethylating agents can reverse platinum resistance in ovarian cancer, this phase 1 trial tested low-dose decitabine combined with carboplatin in patients with recurrent, platinum-resistant ovarian cancer. This combination was well tolerated and induced biological activity (DNA hypomethylation), supporting further testing in ovarian cancer. Abstract
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DisciplinePediatric OncologyRisk factors for central venous catheter thrombotic complications in children and adolescents with cancer (p NA) Both patient-related and central venous catheter (CVC)-related factors are associated with higher risk of symptomatic CVC occlusion and thrombosis. The results of this study could help physicians, nurses and families in the decision process involved in choosing the type of central venous line to be inserted and could be used to develop future studies for reducing the rate of CVC-related complications. Abstract
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Disease SiteMelanomaHigh response rate after intratumoral treatment with interleukin-2 : Results from a phase 2 study in 51 patients with metastasized melanoma (p NA) Interleukin-2 (IL-2) was injected intratumorally into metastases and elicited complete local responses in 69% of patients with melanoma. In addition, survival rates were high, indicating a possible systemic mode of action for locally applied IL-2. Abstract
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DisciplinePediatric OncologySevere neutropenia at time of port insertion is not a risk factor for catheter-associated infections in children with acute lymphoblastic leukemia (p NA) Severe neutropenia on the day of port-a-catheter insertion did not increase the risk of catheter-associated infections in children with newly diagnosed acute lymphoblastic leukemia (ALL). High-risk precursor B-cell and T-cell ALL were identified as risk factors for late catheter-associated infections. Abstract
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Disease SiteHead and Neck DiseaseGabapentin for the treatment of pain syndrome related to radiation-induced mucositis in patients with head and neck cancer treated with concurrent chemoradiotherapy (p NA) Gabapentin was examined as possible therapy for pain in patients with head and neck malignancies treated with concurrent chemoradiotherapy. Gabapentin appeared promising in reducing the need for high total doses of narcotic pain medication and reducing unplanned treatment interruptions. Abstract
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Gynecologic OncologyQuantitative DNA methylation analysis detects cervical intraepithelial neoplasms type 3 and worse (p NA) Quantitative methylation analysis of 4 genes in a full spectrum of cervical lesions was able to detect cervical intraepithelial neoplasia type 3 or worse with high accuracy. The results validated the clinical potential of quantitative methylation analysis, and the authors believe that the application of these new biomarkers will be clinically important in the next generation of cervical cancer screening. Abstract
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MelanomaPrognostic factors derived from a prospective database dictate clinical biology of anal cancer : The intergroup trial (RTOG 98-11) (p NA) A total of 644 prospectively treated patients with anal carcinoma were analyzed to derive prognostic factors. The resulting data establish tumor diameter as an independent prognosticator of poorer disease-free survival (DFS) and overall survival (OS) and confirm clinically positive nodes and male sex as poor prognostic factors. This analysis also uncovers novel subgroups (derived from combining prognostic factors) with incremental worsening of DFS and OS. Abstract
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DisciplineTranslational ResearchEpigenetic and genetic silencing of CHFR in esophageal adenocarcinomas (p NA) The checkpoint with forkhead-associated domain and RING-finger domain (CHFR) is a mitotic checkpoint protein with tumor-suppressor functions. The authors demonstrate that both epigenetic and genetic mechanisms are involved in silencing CHFR expression in esophageal adenocarcinomas. Abstract
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Disease SiteMelanomaPrognostic factors in cutaneous desmoplastic melanoma : A study of 252 patients (p NA) The authors investigated important prognostic factors in patients with clinically localized, primary, cutaneous desmoplastic melanoma. The sentinel lymph node-positive rate was lower in patients with desmoplastic melanoma than in patients with conventional melanoma. The results indicated that the extent of tumor desmoplasia is associated significantly and independently with the time to recurrence and should be evaluated routinely in patients with desmoplastic melanoma. Abstract
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Breast DiseasePopulation-based analysis of occult primary breast cancer with axillary lymph node metastasis (p NA) A population-based analysis using the Surveillance, Epidemiology, and End Results database was conducted to assess practice patterns and outcomes in patients with occult primary breast cancer and axillary lymph node metastasis. Definitive locoregional treatment with either mastectomy or breast-conserving therapy improved the outcome of patients with this presentation, and no difference was observed between the treatments. Abstract
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DisciplineSymptom Control and Palliative CareTiming of palliative care referral and symptom burden in phase 1 cancer patients : A retrospective cohort study (p NA) In this retrospective cohort study, the authors found that phase 1 outpatients referred to palliative care had a better performance status but similar symptom burden compared with non-phase 1 patients. Phase 1 involvement did not appear to delay palliative care referral compared with patients not in phase 1, supporting the development of a simultaneous care model. Abstract
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Pediatric OncologyNoninvasive imaging with thallium-201 scintigraphy may not correlate with survival in patients with osteosarcoma (p NA) Although thallium-201 (T1-201) scintigraphic response to preoperative chemotherapy has previously been shown to correlate with histologic response, in this series of 22 patients with osteosarcoma, Tl-201 scintigraphic response to preoperative chemotherapy did not appear to correlate with event-free survival. It is necessary to use robust outcome variables and not rely on surrogates for outcome to evaluate potential prognostic factors. Abstract
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Disease SiteLung DiseaseIntra-arterial iodine-131-lipiodol for unresectable hepatocellular carcinoma (p NA) Iodine-131-Lipiodol is an appropriate palliative treatment, with encouraging survival outcomes for patients with unresectable exclusively intrahepatic hepatocellular carcinoma. Its best achieved therapeutic effect is in patients with multiple small tumors. Abstract
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Elevated pretreatment serum concentration of YKL-40 - An independent prognostic biomarker for poor survival in patients with metastatic nonsmall cell lung cancer (p NA) In this study, pretreatment serum levels of the glycoprotein YKL-40 were determined in 189 patients who had metastatic nonsmall cell lung cancer (NSCLC). The YKL-40 serum level was identified as a new independent prognostic biomarker in patients with metastatic NSCLC. Abstract
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DisciplineMedical OncologyPhase 1 and pharmacokinetic study of everolimus, a mammalian target of rapamycin inhibitor, in combination with docetaxel for recurrent/refractory nonsmall cell lung cancer (p NA) This phase 1 study demonstrates the safety of combining everolimus, a mammalian target of rapamycin inhibitor, with docetaxel for patients with advanced nonsmall cell lung cancer (NSCLC). Everolimus pharmacokinetics was unaffected on coadministration with docetaxel, and the combination demonstrated efficacy in refractory NSCLC. Abstract
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ErratumErratum: Alemtuzumab by continuous intravenous infusion followed by subcutaneous injection plus rituximab in the treatment of patients with chronic lymphocytic leukemia recurrence (p NA) Abstract | Full Text:
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Original ArticlesDisease SiteMelanomaBevacizumab and everolimus in the treatment of patients with metastatic melanoma : A phase 2 trial of the Sarah Cannon Oncology Research Consortium (p NA) This phase 2 trial evaluated the activity and tolerability of the combination of the antiangiogenic agent bevacizumab with the mammalian target of rapamycin (mTOR) inhibitor everolimus in the treatment of patients with metastatic melanoma. Although the combination was found to have moderate activity (median progression-free survival and overall survival of 4 months and 8.6 months, respectively) and was generally well tolerated in these patients, future therapy using bevacizumab and everolimus may be improved by the incorporation of agents that inhibit the mitogen-activated protein kinase (MAPK) pathway. Abstract
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Hematologic MalignanciesPredictors and outcome of acute kidney injury in patients with acute myelogenous leukemia or high-risk myelodysplastic syndrome (p NA) Relatively mild elevations in creatinine are associated with higher mortality in patients with acute leukemia. Strategies to avoid nephrotoxic drugs or fluid overload may be of benefit. Abstract
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DisciplineDisparities ResearchPathologic complete response in breast cancer patients receiving anthracycline- and taxane-based neoadjuvant chemotherapy : Evaluating the effect of race/ethnicity (p NA) Among 2074 breast cancer patients treated with anthracycline- and taxane-based neoadjuvant chemotherapy, race/ethnicity was not found to be significantly associated with pathologic complete response rates. Improved outcomes were observed in Hispanics and a trend toward worse outcomes in black patients, when compared with whites. Abstract
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Disease SiteHematologic MalignanciesReduced versus full doses of irradiation after 3 cycles of combined doxorubicin, bleomycin, vinblastine, and dacarbazine in early stage Hodgkin lymphomas : Results of a randomized trial (p NA) The randomized H97-E trial was designed in 1997 to assess the impact of a slightly reduced, tailored, extended irradiation dose after 3 cycles of combined doxorubicin, bleomycin, vinblastine, and dacarbazine. This treatment did not have an impact on the excellent cure rate among patients with early Hodgkin lymphoma but significantly reduced the rate of 10-year radiation-induced complications. Abstract
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DisciplineClinical TrialsA phase 1 study of hepatic arterial infusion of oxaliplatin in combination with systemic 5-fluorouracil, leucovorin, and bevacizumab in patients with advanced solid tumors metastatic to the liver (p NA) The authors conducted a phase 1 safety/dose-finding study of hepatic arterial infusion (HAI) oxaliplatin combination therapy in patients with advanced cancer and liver metastases. HAI oxaliplatin combined with systemic 5-fluorouracil, leucovorin, and bevacizumab had antitumor activity in patients with advanced cancer and liver metastases and appeared to warrant further study. Abstract
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Disease SiteSarcomaEvaluation of neoadjuvant therapy and histopathologic response in primary, high-grade retroperitoneal sarcomas using the sarcoma nomogram (p NA) Neoadjuvant therapy was not associated with an overall improvement in disease-specific survival (DSS) in patients with primary high-grade retroperitoneal sarcoma compared with the Memorial Sloan-Kettering Cancer Center (MSKCC) Sarcoma Nomogram prediction. Histopathologic response to neoadjuvant therapy was associated with a significantly improved DSS compared with nonresponders and with the MSKCC Sarcoma Nomogram prediction for such patients. Abstract
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Hepatobiliary DiseaseClonal origin of multifocal hepatocellular carcinoma (p NA) The majority of patients with multifocal hepatocellular carcinomas have common clonal origin. A better understanding of the genetic relationships between multiple tumors may be clinically important in assessing prognosis and selecting therapeutic options in these patients. Abstract
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Review ArticlesEmerging clinical principles on the use of bevacizumab for the treatment of malignant gliomas (p NA) Bevacizumab, a vascular endothelial growth factor antibody, has been granted US Food and Drug Administration approval as a single agent for the treatment of previously treated glioblastoma and is associated with manageable, class-specific toxicity. In this review, the author summarizes the clinical efficacy and safety data on bevacizumab in high-grade gliomas, practical issues regarding its administration, and ongoing investigations in additional brain tumor treatment settings. Abstract
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Original ArticlesDisease SiteGastrointestinal DiseaseIncreased exposure to bacterial antigen RpL7/L12 in early stage colorectal cancer patients (p NA) The humoral immune response to bacterial antigen RpL7/L12 is significantly increased in early stage colorectal cancer patients. This provides clinical support for the hypothesis that certain intestinal bacteria constitute a risk factor for the progression of premalignant lesions into early stage carcinomas Abstract
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CorrespondenceReply to Clinical practice patterns and cost effectiveness of human epidermal growth receptor 2 testing strategies in breast cancer patients (p NA) Abstract
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EditorialsHigh-intensity focused ultrasound in the treatment of bone tumors : Another treatment option for palliation and primary treatment? (p NA) High-intensity focused ultrasound (HIFU) is a new therapy for the treatment of primary and metastatic bone tumors. Well-designed clinical trials are necessary comparing HIFU to commonly accepted treatments before we know the exact role of this new modality. Abstract
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Original ArticlesDisciplineRadiation OncologyNoninvasive treatment of malignant bone tumors using high-intensity focused ultrasound (p NA) High-intensity focused ultrasound (HIFU) can safely and noninvasively ablate malignant bone tumors and relieve pain. For limb bone tumors, limbs could be salvaged after HIFU treatment. Thus, HIFU ablation could be recommended for the treatment of malignant bone tumor. Abstract
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Spinal cord sparing reirradiation with helical tomotherapy (p NA) Helical tomotherapy makes reirradiation of spinal metastases with full therapeutic dose and excellent avoidance of the spinal cord possible and achieves good pain relief and local control. Tailor-made dose distributions with steep dose gradients around previously irradiated tissue are obtained and precisely applied with daily megavoltage computed tomography-based image guidance. Abstract
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CorrespondenceClinical practice patterns and cost-effectiveness of human epidermal growth receptor 2 testing strategies in breast cancer patients (p NA) Abstract
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Original ArticlesDisciplineDisparities ResearchEthnic differences in chronic health conditions after hematopoietic cell transplantation : A report from the Bone Marrow Transplant Survivor Study (p NA) In this study, the authors investigated the burden of morbidity in long-term Hispanic survivors of hematopoietic stem cell transplantation (HCT) compared with their white, non-Hispanic counterparts and examined the role of sociodemographic factors to explain the observed differences. The results indicated that Hispanics are less likely to report severe/life-threatening health conditions after HCT than white non-Hispanics - a difference that decreased in magnitude and significance after taking health insurance into consideration. Abstract
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Disease SiteGastrointestinal DiseaseIntravenous delivery of the plasma fraction of stored packed erythrocytes promotes pancreatic cancer growth in immunocompetent mice (p NA) The plasma fraction of stored packed erythrocytes promoted cellular proliferation and migration. Under controlled surgical conditions, administration of the plasma fraction of packed erythrocytes promoted pancreatic cancer growth. Abstract
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DisciplineClinical TrialsDasatinib in imatinib-resistant or imatinib-intolerant chronic myeloid leukemia in blast phase after 2 years of follow-up in a phase 3 study : Efficacy and tolerability of 140 milligrams once daily and 70 milligrams twice daily (p NA) Dasatinib at a dose of 70 mg twice daily was effective in patients who had blast-phase chronic myelogenous leukemia that was resistant to or intolerant of imatinib. The current results demonstrated that dasatinib 140 mg once daily was similarly effective and offered the likelihood of better tolerability. Abstract
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CorrespondencePhysicians and end-of-life issues (p NA) Abstract
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Reply to Physicians and end-of-life issues (p NA) Abstract
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Original ArticlesDisease SiteSarcomaRandomized trial of paclitaxel versus pegylated liposomal doxorubicin for advanced human immunodeficiency virus-associated Kaposi sarcoma : Evidence of symptom palliation from chemotherapy (p NA) Pegylated liposomal doxorubicin and paclitaxel appear to be active first-line agents for the treatment of advanced, symptomatic Kaposi sarcoma (KS), producing comparable clinical outcomes but with somewhat different adverse event profiles. Chemotherapy may provide clinical benefits with respect to KS-related symptoms, even among those individuals not meeting the criteria for objective tumor response. Abstract
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ChestCancer of the esophagus and esophagogastric junction : Data-driven staging for the seventh edition of the American Joint Committee on Cancer/International Union Against Cancer Cancer Staging Manuals (p NA) A data-driven staging system for cancer of the esophagus and esophagogastric junction was constructed using novel, machine learning techniques from worldwide esophagectomy experience for the seventh edition of the American Joint Committee on Cancer/International Union Against Cancer cancer staging manuals. It was based on both anatomic and nonanatomic cancer characteristics and was harmonized with stomach cancer staging. Abstract
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Hematologic MalignanciesThe efficacy and safety of lenalidomide plus dexamethasone in relapsed and/or refractory multiple myeloma patients with impaired renal function (p NA) In this retrospective subanalysis of data from 2 large phase 3 studies, the authors evaluated the effect of renal impairment, as defined by calculated creatinine clearance, on the outcomes of patients with relapsed and/or refractory multiple myeloma who received treatment with lenalidomide plus dexamethasone. With careful monitoring of calculated creatinine clearance level and adverse events followed by appropriate dose adjustments, lenalidomide plus dexamethasone was an effective and well tolerated treatment option for multiple myeloma in patients with renal impairment. Abstract
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Long-term outcomes for patients with limited stage follicular lymphoma : Involved regional radiotherapy versus involved node radiotherapy (p NA) Disease recurrence after 10 years was uncommon in patients with limited stage follicular lymphoma who received radiotherapy alone, suggesting that a cure is possible. Reducing the radiotherapy field size did not compromise long-term outcomes. Abstract
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SarcomaPlatelet-derived growth factor receptor Imatinib mesylate caused increased cell sensitivity to tumor necrosis factor-related apoptosis-inducing ligand. Combination therapy reduced tumor growth and decreased metastasis in this preclinical Ewing sarcoma study. Abstract
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DisciplineRadiation OncologyImproved survival in patients with early stage low-grade follicular lymphoma treated with radiation : A Surveillance, Epidemiology, and End Results database analysis (p NA) Upfront radiation therapy was associated with improved disease-specific and overall survival compared with alternate management approaches. This benefit suggests that salvage therapies on progression/relapse do not compensate for inadequate initial definitive treatment. Abstract
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Disparities ResearchTrends in PSA, age and prostate cancer detection among black and white men from 1990-2006 at a tertiary care center (p NA) Despite local screening campaigns, recommended younger age at screening, lower prostate-specific (PSA) thresholds, and age at time of diagnostic prostate biopsies in black and white men has not changed during a 16-year period at our tertiary care center. More recent analysis indicates that the PSA was becoming less useful in predicting cancer on subsequent prostate biopsy. Abstract
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Disease SiteHematologic MalignanciesOutcome of patients with myelodysplastic syndrome after failure of decitabine therapy (p NA) The prognosis of patients with myelodysplastic syndrome after decitabine failure is not known. In the current study, 13 (15%) patients remained alive after a median of 21 months from decitabine failure; the median survival was 4.3 months, and the estimated 12-month survival was 28%. The outcome of patients after decitabine failure is poor and appears predictable. Abstract
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Germ cell-specific heat shock protein 70-2 is expressed in cervical carcinoma and is involved in the growth, migration, and invasion of cervical cells (p NA) Strong associations between heat shock protein 70-2 (HSP70-2) expression and early stage and different grades of cervical cancer were observed. The potential role of HSP70-2 in cellular growth and motility supports its implications for early detection and aggressive treatment modalities in cervical cancer treatment and, thus, warrants further studies. Abstract
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Hodgkin lymphoma involving extranodal and nodal head and neck sites : Characteristics and outcomes (p NA) Hodgkin lymphoma of the head and neck is primarily diagnosed as early stage disease in mostly young to middle-aged men. Chemotherapy and adjuvant radiotherapy offer excellent long-term local and systemic control in these patients. Abstract
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DisciplineRadiation OncologyA survey of image-guided radiation therapy use in the United States (p NA) Image-guided radiation therapy (IGRT) has been implemented widely in the United States; however, the current results indicated that the majority of radiation oncologists use it infrequently. IGRT use appears to be increasing, and further research is needed to determine its safety, cost efficacy, and optimal application. Abstract
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Disease SiteGastrointestinal DiseaseComparison of intensity-modulated radiotherapy and 3-dimensional conformal radiotherapy as adjuvant therapy for gastric cancer (p NA) Clinical outcomes in patients treated with postoperative chemoradiotherapy for gastric and gastroesophageal junction cancers using intensity-modulated radiotherapy (IMRT) versus 3-dimensional conformal radiotherapy were found to be similar. IMRT provided better sparing to the liver and possibly to renal function and was associated with less frequent treatment breaks. Abstract
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Hematologic MalignanciesSurveillance imaging of Hodgkin lymphoma patients in first remission : A clinical and economic analysis (p NA) For Hodgkin lymphoma patients in first remission, surveillance radiography is expensive and yields significant radiation exposure. Surveillance positron emission tomography/computed tomography appears to offer no advantage over computed tomography scans in the detection of recurrent lymphoma or secondary malignancy. Abstract
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DisciplineRadiation OncologyLong-term outcome in localized extranodal mucosa-associated lymphoid tissue lymphomas treated with radiotherapy (p NA) Patients with stage I and II mucosa-associated lymphoid tissue (MALT) who received radiotherapy (RT) were studied. Localized extranodal MALT lymphomas can be successfully treated with moderate-dose RT with long-term control rates and minimal toxicity. Abstract
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Quality of LifeHealth-related quality of life in patients with spinal metastases treated with or without spinal surgery : A prospective, longitudinal study (p NA) Patient quality of life (QOL) was assessed at 5 time points - at initial diagnosis (baseline) and at 1 month, 3 months, 6 months, and 9 months of follow-up - using the Functional Assessment of Cancer Therapy-General QOL questionnaire. The results from those assessments suggested that surgical treatment greatly improved the QOL of patients with spinal metastases but did not prolong survival. Abstract
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Outcomes ResearchHighly predictive survival nomogram after upper urinary tract urothelial carcinoma (p NA) Compared with the International Union Against Cancer (UICC) staging system, the current nomogram is capable of predicting more accurately the prognosis for patients with upper urinary tract urothelial carcinoma who were treated with nephroureterectomy. The authors recommend the application of this nomogram to routine clinical practice during counseling or when making clinical decisions. Abstract
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Disease SiteGastrointestinal DiseaseCytoreductive surgery and hyperthermic intraperitoneal chemoperfusion versus systemic chemotherapy alone for colorectal peritoneal carcinomatosis (p NA) Peritoneal carcinomatosis from colorectal cancer has been traditionally viewed as a terminal disease with limited treatment options and published median survival of 5 to 12 months. The authors have observed longer median survival among patients with peritoneal carcinomatosis treated with modern era chemotherapy (16.8 months), and longer among those treated with cytoreduction-hyperthermic intraperitoneal chemoperfusion (34.7 months). Results of this study support the role of cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion for selected patients with colorectal carcinomatosis. Abstract
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DisciplineQuality of LifeEffects of epidermal growth factor receptor inhibitor-induced dermatologic toxicities on quality of life (p NA) In this analysis, the authors used a brief quality-of-life measure for patients with skin diseases to assess the impact of dermatologic toxicities from the use of epidermal growth factor receptor inhibitors (EGFRIs). The results indicated that EGFRI use had a significant impact on patient quality of life. Abstract
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translocation
renal cell carcinoma (RCC), bearing transcription factor E3 (TFE3) gene fusions at Xp11.2, is a recently recognized unique entity for which prognosis and therapy remain poorly understood. The results of the current study indicated that vascular endothelial growth factor-targeted therapy is active in adult translocation RCC.
4 ng/mL is associated with a higher risk of death from prostate cancer.
2-microglobulin, and gender, appear to be prognostic factors in patients with MZL.
ska, Magdalena Murawska, Katarzyna Pogoda
inhibition increases tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitivity : Imatinib and TRAIL dual therapy (p NA)
